{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:01:05Z","timestamp":1790762465598,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2003,8,7]],"date-time":"2003-08-07T00:00:00Z","timestamp":1060214400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, the hepatoprotective action of <jats:italic>Limonium sinense<\/jats:italic> (Plumbaginaceae) was evident after carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) and <jats:italic>\u03b2<\/jats:italic>\u2010D\u2010galactosamine (D\u2010GalN), respectively, challenge in rats. The plant materials were divided into two parts: (1) the roots extracted with water (WRE) and (2) the leaves extracted with methanol and fractionated with chloroform (CLE). Both WRE and CLE were extremely \ufb02avonoid\u2010enriched extracts.<\/jats:p><jats:p>In an CCl<jats:sub>4<\/jats:sub>\u2010induced acute liver damage study, pretreatment with WRE at 300 mg\/kg <jats:italic>i.p.<\/jats:italic> and CLE at 100 mg\/kg <jats:italic>i.p.<\/jats:italic> signi\ufb01cantly reduced the amino\u2010transaminases levels of SGOT (<jats:italic>p<\/jats:italic> &lt; 0.01) and SGPT (<jats:italic>p<\/jats:italic> &lt; 0.01) previously increased by CCl<jats:sub>4<\/jats:sub> intoxication. In D\u2010GalN\u2010induced acute liver damage study, administration of WRE (300 and 500 mg\/kg) or CLE (100 mg\/kg) <jats:italic>p.o.<\/jats:italic> also signi\ufb01cantly reduced the SGOT (<jats:italic>p<\/jats:italic> &lt; 0.01) and SGPT (<jats:italic>p<\/jats:italic> &lt; 0.01) levels previously increased by D\u2010GalN intoxication. Furthermore, the serum triglyceride level was increased after pretreatment with WRE or CLE previously reduced by D\u2010GalN intoxication. All of the liver function pro\ufb01les were con\ufb01rmed to have improvement of liver lesion in histopathological obsvervation.<\/jats:p><jats:p>In an acute toxicity test on ICR mice, the LD<jats:sub>50<\/jats:sub> of WRE was 777.6 mg\/kg <jats:italic>i.p.<\/jats:italic> An <jats:italic>in vitro<\/jats:italic> study showed that CLE possessed a more potent cytotoxicity to human hepatocellular carcinoma cells (Hep3B) (EC<jats:sub>50<\/jats:sub> = 43.1 \u00b5g\/mL) than the other organic fractions, which were fractionated from methanol extracts of the leaves of <jats:italic>L. sinense<\/jats:italic>. The present results conclude that <jats:italic>L. sinense<\/jats:italic> possesses a hepatoprotective ef\ufb01cacy, and is relatively safe in rats. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1236","type":"journal-article","created":{"date-parts":[[2003,8,8]],"date-time":"2003-08-08T13:19:18Z","timestamp":1060348758000},"page":"784-791","source":"Crossref","is-referenced-by-count":34,"title":["The hepatoprotective effects of <i>Limonium sinense<\/i> against carbon tetrachloride and <i>\u03b2<\/i>\u2010D\u2010galactosamine intoxication in 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