{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:21:08Z","timestamp":1783808468077,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,9,11]],"date-time":"2003-09-11T00:00:00Z","timestamp":1063238400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of <jats:italic>Nigella sativa<\/jats:italic> L. (Ranunculaceae) (NS) and <jats:italic>Urtica dioica<\/jats:italic> L. was investigated (UD) in the prevention of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) induced liver \ufb01brosis and cirrhosis. Fifty Sprague\u2010Dawley rats were allocated into \ufb01ve groups (I, IIA and B, IIIA and B) and CCl<jats:sub>4<\/jats:sub> was injected biweekly to all groups. Group I (control, CCl<jats:sub>4<\/jats:sub> only), group IIA and B (NS \ufb01xed oil and volatile oil), group IIIA and B (UD \ufb01xed oil and UD decoction extract) rats were killed at the end of week 12 and histopathological and immunohistochemical examinations of liver tissues were performed. In the control group, coagulation necrosis and hydropic degeneration were marked in the periacinar regions (zone 3) associated with \ufb01brosis in the periacinar regions and in the portal tracts. In groups IIA\u2013B and IIIA\u2013B (NS and UD), none of the serious histopathological \ufb01ndings were detected except for sparse coagulation necrosis in the periacinar regions. ASMA\u2010positive perisinusoidal cells with myo\ufb01broblastic transformation and lysosomal enzyme activity suggesting \ufb01brogenesis were also signi\ufb01cantly more common in the control group than in the NS and UD groups. UD and NS seem to be signi\ufb01cantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1266","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T13:05:39Z","timestamp":1063631139000},"page":"942-946","source":"Crossref","is-referenced-by-count":50,"title":["The role of <i>Urtica dioica<\/i> and <i>Nigella sativa<\/i> in the prevention of carbon tetrachloride\u2010induced hepatotoxicity in rats"],"prefix":"10.1002","volume":"17","author":[{"given":"M. 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