{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:39:22Z","timestamp":1783528762193,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T00:00:00Z","timestamp":1067212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Kangen\u2010Karyu<\/jats:italic> (KGK), containing peony root, cnidium rhizome, saf\ufb02ower, cyperus rhizome, saussurea root and <jats:italic>Salvia miltiorrhiza<\/jats:italic> root, is a Chinese traditional medicine formula to invigorate the \u2018blood\u2019 and dispel \u2018blood stasis\u2019, arising from poor blood circulation. The present study evaluated the pharmacokinetic and pharmacological interactions between KGK and ticlopidine hydrochloride. Ticlopidine was administered orally or intravenously to KGK\u2010treated rats, and its plasma concentrations were measured. KGK did not signi\ufb01cantly affect the pharmacokinetic parameters of ticlopidine in rats treated with both oral and intravenous administration. Ticlopidine alone signi\ufb01cantly prolonged the mouse tail\u2010bleeding time and adenosine 5\u2032\u2010diphosphate\u2010induced <jats:italic>ex vivo<\/jats:italic> platelet aggregation, which was slightly augmented by KGK. It is suggested that the combined therapy of ticlopidine and KGK may augment the antithrombotic effects, and that the dosage of ticlopidine should be reduced to prevent thrombotic thrombocytopenic purpura, a severe adverse effect of ticlopidine. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1286","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T08:01:35Z","timestamp":1067328095000},"page":"1021-1024","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacokinetic and pharmacological interactions between ticlopidine hydrochloride and <i>Kangen\u2010Karyu<\/i> \u2013 Chinese traditional herbal medicine"],"prefix":"10.1002","volume":"17","author":[{"given":"Toshiaki","family":"Makino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannosuke","family":"Wakushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Okukubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.19.1548"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1995.tb05819.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19029"},{"key":"e_1_2_1_5_1","first-page":"1239","article-title":"Herbal remedies: adverse effects and drug interactions","volume":"59","author":"Cupp MJ","year":"1999","journal-title":"Am Fam Physician"},{"key":"e_1_2_1_6_1","first-page":"245","article-title":"Studies on preventive effect of \u2018Kangenkaryu\u2019, Chinese herbal medicine, on stroke in SHR\u2010SP","volume":"18","author":"Gao M","year":"2001","journal-title":"J Trad Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92327-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908243210804"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(81)90230-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190157"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.523"},{"key":"e_1_2_1_12_1","volume-title":"Chinese Herbal Medicine","author":"Reid D","year":"1987"},{"key":"e_1_2_1_13_1","first-page":"286","article-title":"Moment analysis program available on Microsoft Excel\u00ae","volume":"14","author":"Tabata K","year":"1999","journal-title":"Xenobio Metabol Dispos"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.60.307"},{"key":"e_1_2_1_15_1","first-page":"667","article-title":"Clinical application of Kangenkaryu \u2013 including comparison with Western medicine","volume":"3","author":"Tanaka N","year":"1993","journal-title":"Clin Pharm Ther"},{"key":"e_1_2_1_16_1","volume-title":"The Japanese Pharmacopoeia","author":"The Society of Japanese Pharmacopoeia","year":"2001"},{"key":"e_1_2_1_17_1","first-page":"461","article-title":"The effect of composite Guan\u2010Xin No.2 on myocardial ischemia and hypoxia in experimental animals","volume":"14","author":"Xu LN","year":"1979","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01062109"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.4.879"},{"key":"e_1_2_1_20_1","volume-title":"Patterns and Practice in Chinese Medicine","author":"Zhao J","year":"1998"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:41:33Z","timestamp":1700246493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,27]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/ptr.1286"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1286","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,27]]}}}