{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:06:41Z","timestamp":1773662801525,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,1,23]],"date-time":"2004-01-23T00:00:00Z","timestamp":1074816000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of various doses of 50% ethanolic extract of chyavanaprasha (an Ayurvedic rejuvenating herbal preparation) was studied on the survival of mice exposed to 10 Gy of <jats:italic>\u03b3<\/jats:italic>\u2010radiation. Treatment with chyavanaprasha, consecutively for \ufb01ve days before irradiation, delayed symptoms of radiation sickness and onset of mortality when compared with the non\u2010drug treated irradiated controls. All doses of chyavanaprasha provided a signi\ufb01cant protection against gastrointestinal (GI) death (death of animals within 10 days after exposure to radiation), however, highest protection against GI death was observed for 15 mg\/kg chyavanaprasha. Chyavanaprasha also provided a signi\ufb01cant protection against the bone marrow death after 10 to 40 mg\/kg. However, the best protection was seen for 15 mg\/kg, where the highest number of survivors was observed at the end of 30 days post\u2010irradiation. The drug was non\u2010toxic up to a dose of 6 g\/kg b. wt., the highest drug dose that could be tested. Our study demonstrates that chyavanaprasha can provide good radioprotection at a very low non\u2010toxic dose. 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