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Treatment with Vimang or mangiferin (500 or 50 mg per kg body weight per day, respectively) throughout the parasite life cycle led to a signi\ufb01cant decline in the number of parasite larvae encysted in the musculature; however, neither treatment was effective against adults in the gut. Treatment with Vimang or mangiferin likewise led to a signi\ufb01cant decline in serum levels of speci\ufb01c anti\u2010<jats:italic>Trichinella<\/jats:italic> IgE, throughout the parasite life cycle. Finally, oral treatment of rats with Vimang or mangiferin, daily for 50 days, inhibited mast cell degranulation as evaluated by the passive cutaneous anaphylaxis test (sensitization with infected mouse serum with a high IgE titre, then stimulation with the cytosolic fraction of <jats:italic>T. spiralis<\/jats:italic> muscle larvae). Since IgE plays a key role in the pathogenesis of allergic diseases, these results suggest that Vimang and mangiferin may be useful in the treatment of diseases of this type. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1343","type":"journal-article","created":{"date-parts":[[2003,12,8]],"date-time":"2003-12-08T08:01:53Z","timestamp":1070870513000},"page":"1203-1208","source":"Crossref","is-referenced-by-count":80,"title":["Anthelminthic and antiallergic activities of <i>Mangifera indica<\/i> L. stem bark components Vimang and mangiferin"],"prefix":"10.1002","volume":"17","author":[{"given":"D.","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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