{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:06:50Z","timestamp":1789394810603,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,9,11]],"date-time":"2003-09-11T00:00:00Z","timestamp":1063238400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increase of multidrug\u2010resistant <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (MDR\u2010TB) demands the search for alternative antimycobacterial drugs. The aim of this study was to evaluate plants used in Mexican traditional medicine to treat respiratory diseases for activity against MDR\u2010TB. A group of 22 plants was screened for activity against <jats:italic>Mycobacterium tuberculosis H37Rv<\/jats:italic> and <jats:italic>Mycobacterium avium<\/jats:italic> at concentrations from 50 to 200 \u00b5g\/mL. The antimycobacterial effect was determined by a microcolorimetric assay with Alamar blue dye. None of the aqueous extracts had antimycobacterial activity. Hexane extracts from <jats:italic>Artemisia ludoviciana<\/jats:italic>, <jats:italic>Chamaedora tepejilote<\/jats:italic>, <jats:italic>Lantana hispida<\/jats:italic>, <jats:italic>Juniperus communis<\/jats:italic> and <jats:italic>Malva parvi\ufb02ora<\/jats:italic>, and methanol extracts from <jats:italic>Artemisia ludoviciana<\/jats:italic> and <jats:italic>Juniperus communis<\/jats:italic> inhibited the growth of <jats:italic>Mycobacterium tuberculosis<\/jats:italic>. <jats:italic>Mycobacterium avium<\/jats:italic> was inhibited by <jats:italic>Juniperus communis<\/jats:italic> hexane extract and by <jats:italic>Malva parvi\ufb02ora<\/jats:italic> methanol extract. The active extracts were tested against monoresistant variants of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> H37Rv (isoniazid, rifampin, streptomycin and ethambutol resistant) and the hexane extract of <jats:italic>Lantana hispida<\/jats:italic> showed the best activity. <jats:italic>Lantana hispida<\/jats:italic> hexane extract was also active against a group of MDR\u2010TB clinical isolates. In contrast, it did not inhibit the growth of non\u2010tuberculous mycobacteria. The hexane extract of <jats:italic>Lantana hispida<\/jats:italic> was fractionated by column chromatography and one of its fractions (FVI) inhibited the growth of all the MDR\u2010TB clinical isolates at concentrations up to 25 \u00b5g\/mL. This study supports the fact that selecting plants by ethnobotanical criteria enhances the probability of \ufb01nding species with activity against mycobacteria, and our results point to <jats:italic>Lantana hispida<\/jats:italic> as an important source of potential compounds against MDR\u2010TB. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1377","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T13:05:39Z","timestamp":1063631139000},"page":"903-908","source":"Crossref","is-referenced-by-count":121,"title":["Activity against multidrug\u2010resistant <i>Mycobacterium tuberculosis<\/i> in Mexican plants used to treat respiratory diseases"],"prefix":"10.1002","volume":"17","author":[{"given":"Adelina","family":"Jimenez\u2010Arellanes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Meckes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Luna\u2010Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Herbario Medicinal del Instituto Mexicano del Seguro Social. 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