{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:09:06Z","timestamp":1790201346187,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:00:00Z","timestamp":1084838400000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Valerian is the common name given to the crude drug consisting of the underground organs of the species <jats:italic>Valeriana<\/jats:italic>. <jats:italic>Valeriana edulis<\/jats:italic> ssp. <jats:italic>procera<\/jats:italic> Meyer is the Mexican valerian. The aim of the present work was to elucidate the neuropharmacological pro\ufb01le of a hydroalcohol extract of <jats:italic>Valeriana edulis<\/jats:italic> roots at doses of 100, 300 and 1000 mg\/kg in several experimental models. A dose\u2010dependent anticonvulsant and anxiolytic\u2010like effect of <jats:italic>V. edulis<\/jats:italic> was demonstrated. In addition, the extract decreased rotarod performance and traction force and prolonged the pentobarbital\u2010induced sleeping time at high doses. Concomitant administration of valerian extract and pentobarbital showed a synergistic effect on motor coordination and traction force in mice. The anxiolytic\u2010like effect of <jats:italic>V. edulis<\/jats:italic> was compared with diazepam and with diphenhydramine and doxylamine, the latter in order to consider the H<jats:sub>1<\/jats:sub>\u2010antihistamine effect as another possibility to explain, at least in part, the central nervous system depressant effect of valerian. These results also underlie the medical and industrial use of this species and allowed the conclusion that the extract of <jats:italic>V. edulis<\/jats:italic> has central nervous depressant properties similar to, but with some differences to <jats:italic>V. of\ufb01cinalis<\/jats:italic>, a very well known species. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1389","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T15:02:31Z","timestamp":1084892551000},"page":"290-296","source":"Crossref","is-referenced-by-count":39,"title":["Neuropharmacological pro\ufb01le of hydroalcohol extract of <i>Valeriana edulis<\/i> ssp. <i>procera<\/i> roots in mice"],"prefix":"10.1002","volume":"18","author":[{"given":"Iv\u00e1n","family":"Oliva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. Eva","family":"Gonz\u00e1lez\u2010Trujano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Arrieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Enciso\u2010Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1565(199605)7:3<143::AID-PCA284>3.0.CO;2-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957392"},{"key":"e_1_2_1_4_1","first-page":"220","article-title":"Synaptosomal GABA release as influenced by valerian root extract\u2010involvement of the GABA carrier","volume":"327","author":"Carvalho AP","year":"1994","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0104267"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(82)90264-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90013-9"},{"key":"e_1_2_1_8_1","first-page":"297","article-title":"Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them","volume":"51","author":"Della Loggia R","year":"1981","journal-title":"Riv Neurol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957674"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00110"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(99)00094-5"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969384"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18344"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199603)10:2<145::AID-PTR793>3.0.CO;2-W"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772772"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(82)90264-7"},{"key":"e_1_2_1_17_1","first-page":"638","article-title":"Characterization of the central nervous depressant of the commercially available valerian root extract","volume":"43","author":"Leuschner J","year":"1993","journal-title":"Arzneimittelforsch"},{"key":"e_1_2_1_18_1","volume-title":"Phytopharmaceutical Technology","author":"List PH","year":"1989"},{"key":"e_1_2_1_19_1","volume-title":"Las Plantas Medicinales de M\u00e9xico","author":"Mart\u00ednez M","year":"1990"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022576405534"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200210000-00012"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(87)80197-5"},{"key":"e_1_2_1_23_1","volume-title":"La Flora del Valle de M\u00e9xico","author":"S\u00e1nchez SF","year":"1980"},{"key":"e_1_2_1_24_1","first-page":"1149","article-title":"Zur bestimung der baldrian\u2010droga undihrer zubereitungen","volume":"20","author":"Wagner H","year":"1970","journal-title":"Arztneimittelforschung"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T02:05:34Z","timestamp":1700186734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1002\/ptr.1389"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1389","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}