{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:33:06Z","timestamp":1790080386814,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,5]],"date-time":"2004-03-05T00:00:00Z","timestamp":1078444800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001655","name":"DAAD","doi-asserted-by":"crossref","award":["A\/02\/04833"],"award-info":[{"award-number":["A\/02\/04833"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fond der Chemischen Industrie"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>in vitro<\/jats:italic> superoxide scavenging activity (as determined by electrochemical measurement) and the <jats:italic>in vivo<\/jats:italic> antioxidant potential (as determined by a mouse model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) hepatotoxicity) of methanolic extracts prepared from 10 Chinese tonifying herbs were compared. Electrochemical measurement using a cytochrome <jats:italic>c<\/jats:italic> (Cyt. <jats:italic>c<\/jats:italic>) sensor showed that all of the tested herbal extracts exhibited a medium superoxide scavenging activity of different potency, as indicated by their IC<jats:sub>50<\/jats:sub> values. The <jats:italic>in vivo<\/jats:italic> measurement demonstrated that 80% of the herbal extracts displayed <jats:italic>in vivo<\/jats:italic> antioxidant potential, as assessed by the percentage of protection of the activity of plasma alanine aminotransferases and the hepatic glutathione regeneration capacity under CCl<jats:sub>4<\/jats:sub>\u2010intoxicated condition. Although the <jats:italic>in vitro<\/jats:italic> antioxidant activity did not correlate quantitatively with the <jats:italic>in vivo<\/jats:italic> antioxidant potential, for 8 out of 10 samples a similar tendency was found. The rapid amperometric assessment of antioxidant potential by Cyt. <jats:italic>c<\/jats:italic> sensor may offer a convenient and direct method for screening as well as the quality control of herbal products. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1408","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T08:03:08Z","timestamp":1078819388000},"page":"149-153","source":"Crossref","is-referenced-by-count":18,"title":["Comparing an <i>in vitro<\/i> electrochemical measurement of superoxide scavenging activity with an <i>in vivo<\/i> assessment of antioxidant potential in Chinese tonifying herbs"],"prefix":"10.1002","volume":"18","author":[{"given":"Moritz K.","family":"Beissenhirtz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger C. H.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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