{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:17:29Z","timestamp":1788545849635,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T00:00:00Z","timestamp":1085529600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intravenous administration of the hexane extract of the bark of <jats:italic>Anacardium occidentale<\/jats:italic> (cashew) in normal, healthy dogs produced a signi\ufb01cant lowering of the blood glucose levels. Pursuit of the hypoglycaemic principle(s) in the hexane extract resulted in the isolation and characterization of two compounds, stigmast\u20104\u2010en\u20103\u2010ol (1) and stigmast\u20104\u2010en\u20103\u2010one (2). These compounds were puri\ufb01ed by chromatographic methods and the structures were characterized by spectroscopic methods. Both compounds produced signi\ufb01cant hypoglycaemic activity after intravenous administration at a dose of 1.3 mg\/kg body weight. The bark of the cashew plant, <jats:italic>A. occidentale<\/jats:italic>, exhibited a hypoglycaemic effect probably due to the presence of these compounds. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1459","type":"journal-article","created":{"date-parts":[[2004,5,26]],"date-time":"2004-05-26T17:01:33Z","timestamp":1085590893000},"page":"403-407","source":"Crossref","is-referenced-by-count":56,"title":["Hypoglycaemic effect of stigmast\u20104\u2010en\u20103\u2010one and its corresponding alcohol from the bark of <i>Anacardium occidentale<\/i> (cashew)"],"prefix":"10.1002","volume":"18","author":[{"given":"Ruby Lisa","family":"Alexander\u2010Lindo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.Y. St. A.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muraleedharan G.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,5,26]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"433","volume-title":"Flowering Plants of Jamaica","author":"Adams CD","year":"1972"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00522a061"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198835030-00003"},{"key":"e_1_2_1_5_1","first-page":"128","volume-title":"Pharmacographia Indica: A History of the Principal Drugs of Vegetable Origin","author":"Dymock KW","year":"1972"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50072a005"},{"key":"e_1_2_1_7_1","first-page":"219","article-title":"Acarbose treatment of sulfonylurea\u2010treated non\u2010insulin\u2010dependent diabetics: a double\u2010blind, cross\u2010over comparison of an \u03b1\u2010glucosidase inhibitor with metformin","volume":"10","author":"Johansen K","year":"1984","journal-title":"Diabetes Metab"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03789.x"},{"key":"e_1_2_1_9_1","first-page":"194","article-title":"A preliminary study of the effects of some West Indian medical plants on blood sugar levels in the dog","volume":"31","author":"Morrison FY St. A","year":"1982","journal-title":"W I Med J"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50064a022"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)91252-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(82)90021-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)81911-1"},{"key":"e_1_2_1_14_1","first-page":"391","volume-title":"Volatile Compounds in Foods and Beverages","author":"Winterhalter P","year":"1991"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:25:52Z","timestamp":1700259952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/ptr.1459"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1459","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}