{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:13:59Z","timestamp":1766135639307},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six diterpenoids and two diterpene glycosides were isolated from the dichloromethane and the water fractions of <jats:italic>Acanthopanax koreanum<\/jats:italic> roots, respectively. Of these compounds, 16<jats:italic>\u03b1<\/jats:italic>H, 17\u2010isovaleryloxy\u2010<jats:italic>ent<\/jats:italic>\u2010kauran\u201019\u2010oic acid containing an isovaleryloxy group at C\u201017 was found to exhibit the strongest inhibitory activity (IC<jats:sub>50<\/jats:sub>, 6.7 \u00b5<jats:sc>m<\/jats:sc>) against NFAT transcription factor. However, sumogaside, 16<jats:italic>\u03b1<\/jats:italic>\u2010hydroxy\u2010<jats:italic>ent<\/jats:italic>\u2010kauran\u201019\u2010oic acid and paniculosides IV containing a hydroxy group at C\u201016 or a glycoside at C\u20104 carboxyl acid showed no activity. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1523","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T13:00:50Z","timestamp":1097240450000},"page":"677-680","source":"Crossref","is-referenced-by-count":7,"title":["Diterpenoids with inhibitory activity against NFAT transcription factor from <i>Acanthopanax koreanum<\/i>"],"prefix":"10.1002","volume":"18","author":[{"given":"Xing Fu","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Im Seon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Tien","family":"Dat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghai","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,8]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"315","volume-title":"Cellular and Molecular Imunology","author":"Abbas AK","year":"1997"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5436.2129"},{"key":"e_1_2_1_4_1","first-page":"161","volume-title":"Materia Medica","author":"Bensky D","year":"1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(82)80143-X"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990615a"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(95)80107-3"},{"key":"e_1_2_1_8_1","first-page":"1683","article-title":"Further study on the diterpenes of Aralia spp. Susumu Mihashi","volume":"21","author":"Kashiwagi, Shinjuku K","year":"1969","journal-title":"Tetrahedron Lett"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50060a005"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)99385-2"},{"key":"e_1_2_1_11_1","first-page":"49","article-title":"Diterpene glycoside from Acanthopanax koreanum.","volume":"21","author":"Kim YH","year":"1990","journal-title":"Kor J Pharmacog"},{"key":"e_1_2_1_12_1","first-page":"94","article-title":"NFAT transcription factor inhibitory constituents from Cnidium officinale.","volume":"8","author":"Lee IS","year":"2002","journal-title":"Nat Prod Sci"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37024"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.32.4620"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.25.2895"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2144\/97236pf01"},{"key":"e_1_2_1_17_1","first-page":"673","article-title":"A new kaurane derivative from Aralia fargesii","volume":"10","author":"Zhang YM","year":"1999","journal-title":"Chin Chem Lett"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T02:32:04Z","timestamp":1700188324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["10.1002\/ptr.1523"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1523","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}