{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:13:54Z","timestamp":1768068834348,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"vor","delay-in-days":90,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The stem bark of the Betulaceae plant <jats:italic>Alnus japonica<\/jats:italic>, which is indigenous to Korea, has been used as a popular folk medicine for hepatitis and cancer. In this study, the antioxidant activity of the crude extract and the hepatoprotective activities on acetaminophen (AAP)\u2010induced toxicity in the rat liver were evaluated. We investigated the effect of the methanol (AJM) and solvent fracton of the stem bark of <jats:italic>Alnus japonica<\/jats:italic> (AJ) on AAP\u2010induced hepatotoxicity in rats. In rat hepatocyte culture, pretreatment with AJM (50, 100, 150 and 200 \u00b5g[sol ]ml) significantly decreased the cytotoxicity of AAP in a dose\u2010dependent manner. The pretreated with EtOAc and BuOH fraction led to an increase in free radical scavenging activity and a decrease in inhibition of lipid peroxidation, both superoxide dismutase and catalase prevent the hepatotoxicity by AAP in the treatment of <jats:italic>A. japonica<\/jats:italic> fraction. We conclude that AJ is an important antioxidant in AAP\u2010induced live hepatotoxicity and that extract of AJM plays a hepatoprotective effects in the against AAP\u2010induced cytotoxicity in cultured rat hepatocytes in vitro. Pending more evaluation for safety and efficacy, AJ can potentially be used in mitigating AAP\u2010induced hepatotoxicity. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1540","type":"journal-article","created":{"date-parts":[[2005,3,2]],"date-time":"2005-03-02T11:23:43Z","timestamp":1109762623000},"page":"971-975","source":"Crossref","is-referenced-by-count":25,"title":["Hepatoprotective and antioxidant effects of <i>Alnus japonica<\/i> extracts on acetaminophen\u2010induced hepatotoxicity in rats"],"prefix":"10.1002","volume":"18","author":[{"given":"Sang Tae","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Hee","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu Seok","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoong Seok","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.818"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)00233-A"},{"key":"e_1_2_1_4_1","first-page":"1175","article-title":"Acetaminophen toxicity is substantially reduced by beta\u2010carotene in mice.","volume":"65","author":"Baranowitz SA","year":"1995","journal-title":"Int J Vitam Nutr Res"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199805)12:3<159::AID-PTR209>3.0.CO;2-C"},{"key":"e_1_2_1_6_1","first-page":"159","volume-title":"Toxicology of the Liver","author":"Cohen SD","year":"1998"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00406-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24267"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05014-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx950153d"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2001.00891.x"},{"key":"e_1_2_1_12_1","first-page":"40","volume-title":"Korea Folk Medicine","author":"Lee SL","year":"1996"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.3.382"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.1.6.3315807"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160426"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90167-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072634"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)85286-O"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199806)12:4<288::AID-PTR228>3.0.CO;2-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199908\/09)13:5<422::AID-PTR462>3.0.CO;2-M"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02615128"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1540","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T16:52:09Z","timestamp":1700239929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/ptr.1540"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1540","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}