{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:23:11Z","timestamp":1759530191465},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T00:00:00Z","timestamp":1100822400000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In order to reduce the haemolytic susceptibility of glucose\u20106\u2010phosphate dehydrogenase (G\u20106\u2010PD) de\ufb01cient erythrocytes, <jats:italic>Ginkgo biloba<\/jats:italic> extract (EGb 761) and vitamin E (vit E) were used as antioxidant agents and their effects compared. The erythrocyte suspensions from control and G\u20106\u2010PD de\ufb01cient patients were subjected to hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) incubation for 1 h. The produced thiobarbituric acid reactive substance (TBARS) levels measured as nmol\/g Hb were compared with those of the erythrocytes administered 250 \u00b5g\/mL EGb 761 or vit E previously or concomitantly with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Preincubation with EGb 761 reduced the TBARS levels from 317.14 \u00b1 25.27 to 160.09 \u00b1 21.97 nmol\/g Hb in controls and from 348.24 \u00b1 7.79 to 205.60 \u00b1 14.22 nmol\/g Hb in de\ufb01cient erythrocytes. Concomitant application of EGb 761 with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> resulted in similar but less reduction. The antioxidative effects of vitamin E were comparable to those of EGb 761. Contrary to the results obtained from oxidant conditions, the antioxidant characteristics of EGb 761 and vitamin E were not observed when they were applied directly to the erythrocytes without oxidative stress. The \ufb01ndings demonstrate that irrespective of administration time, EGb 761 signi\ufb01cantly reduced TBARS levels in the erythrocytes of control and G\u20106\u2010PD de\ufb01cient patients subjected to oxidative stress. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1544","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T13:18:17Z","timestamp":1100870297000},"page":"837-840","source":"Crossref","is-referenced-by-count":18,"title":["Antioxidant effect of EGb 761 on hydrogen peroxide\u2010induced lipoperoxidation of G\u20106\u2010PD de\ufb01cient erythrocytes"],"prefix":"10.1002","volume":"18","author":[{"given":"S\u00fcreyya 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