{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:15:33Z","timestamp":1780676133499,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T00:00:00Z","timestamp":1112140800000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antiallergic properties of two lyophilized extracts obtained from <jats:italic>Capparis spinosa<\/jats:italic> L. flowering buds (capers) by methanol extraction, carried out at room temperature (CAP\u2010C) or with heating at 60 \u00b0C (CAP\u2010H), were investigated.<\/jats:p><jats:p>The protective effects of CAP\u2010H and CAP\u2010C, orally administered (14.28 mg[sol ]kg), were evaluated against <jats:italic>Oleaceae<\/jats:italic> antigen challenge\u2010induced and histamine\u2010induced bronchospasm in anaesthetized guinea\u2010pigs. Furthermore, the histamine skin prick test was performed on humans, applying a gel formulation containing 2% CAP\u2010C (the only extract able to protect against histamine\u2010induced bronchospasm) on the skin for 1 h before histamine application and monitoring the erythema by reflectance spectrophotometry.<\/jats:p><jats:p>The CAP\u2010H showed a good protective effect against the bronchospasm induced by antigen challenge in sensitized guinea\u2010pigs; conversely, a significant decrease in the responsiveness to histamine was seen only in CAP\u2010C pretreated animals. Finally, the CAP\u2010C gel formulation possessed a marked inhibitory effect (46.07%) against histamine\u2010induced skin erythema.<\/jats:p><jats:p>These two caper extracts displayed marked antiallergic effectiveness; however, the protective effect of CAP\u2010H was very likely due to an indirect mechanism (for example, inhibition of mediator release from mast cells or production of arachidonic acid metabolites); conversely, CAP\u2010C is endowed with direct antihistaminic properties. The different mechanisms of action of CAP\u2010H and CAP\u2010C may be related to a difference in the extraction procedure and, thus, in their qualitative[sol ]quantitative chemical profile. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1591","type":"journal-article","created":{"date-parts":[[2005,3,30]],"date-time":"2005-03-30T09:16:54Z","timestamp":1112174214000},"page":"29-33","source":"Crossref","is-referenced-by-count":47,"title":["Antiallergic and antihistaminic effect of two extracts of <i>Capparis spinosa<\/i> L. flowering buds"],"prefix":"10.1002","volume":"19","author":[{"given":"Domenico","family":"Trombetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Occhiuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Perri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Puglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natale 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