{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:56:10Z","timestamp":1791269770498,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T00:00:00Z","timestamp":1124668800000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the course of screening Ethiopian medicinal plants for their antimalarial properties, it was found that the dichloromethane extract of the roots of <jats:italic>Kniphofia foliosa<\/jats:italic> Hochst. (Asphodelaceae), which have long been used in the traditional medicine of Ethiopia for the treatment of abdominal cramps and wound healing, displayed strong <jats:italic>in vitro<\/jats:italic> antiplasmodial activity against the chloroquine\u2010sensitive 3D7 strain of <jats:italic>Plasmodium falciparum<\/jats:italic> with an ED<jats:sub>50<\/jats:sub> value of 3.8 \u00b5g\/mL and weak cytotoxic activity against KB cells with an ED<jats:sub>50<\/jats:sub> value of 35.2 \u00b5g\/mL. Five compounds were isolated from the roots and evaluated for their <jats:italic>in<\/jats:italic> <jats:italic>vitro<\/jats:italic> antimalarial activity. Among the compounds tested, 10\u2010(chrysophanol\u20107\u2032\u2010yl)\u201010\u2010(<jats:italic>\u03be<\/jats:italic>)\u2010hydroxychrysopanol\u20109\u2010anthrone and chryslandicin, showed a high inhibition of the growth of the malaria parasite, <jats:italic>P. falciparum<\/jats:italic> with ED<jats:sub>50<\/jats:sub> values of 0.260 and 0.537 \u00b5g\/mL, respectively, while the naphthalene derivative, 2\u2010acetyl\u20101\u2010hydroxy\u20108\u2010methoxy\u20103\u2010methylnaphthalene, exhibited a less significant antimalarial activity with an ED<jats:sub>50<\/jats:sub> value of 15.4 \u00b5g\/mL. To compare the effect on the parasite with toxicity to mammalian cells, the cytotoxic activities of the isolated compounds against the KB cell line were evaluated and 10\u2010(chrysophanol\u20107\u2032\u2010yl)\u201010\u2010(<jats:italic>\u03be<\/jats:italic>)\u2010hydroxychrysopanol\u20109\u2010anthrone and chryslandicin displayed very low toxicity with ED<jats:sub>50<\/jats:sub> values of 104 and 90 \u00b5g\/mL, respectively. This is the first report of the inhibition of the growth of <jats:italic>P. falciparum<\/jats:italic> by anthraquinone\u2010anthrone dimers and establishes them as a new class of potential antimalarial compounds with very little host cell toxicity. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1635","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T08:47:29Z","timestamp":1124700449000},"page":"472-476","source":"Crossref","is-referenced-by-count":50,"title":["Antimalarial compounds from <i>Kniphofia foliosa<\/i> roots"],"prefix":"10.1002","volume":"19","author":[{"given":"Abraham Abebe","family":"Wube","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Bucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaleab","family":"Asres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Rattray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon L","family":"Croft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,22]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Etse Debdabe: Ethiopian Traditional Medicine","author":"Abate G","year":"1989"},{"key":"e_1_2_1_3_1","first-page":"286","article-title":"Two new naphthalene and anthraquinone derivatives from Asphodelus tenuifolius.","volume":"57","author":"Abdel\u2010Mogib M","year":"2002","journal-title":"Pharmazie"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)95104-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np980144f"},{"key":"e_1_2_1_6_1","first-page":"343","article-title":"Antitrypanosomal naphthylisoquinone alkaloids and related compounds","volume":"58","author":"Bringmann G","year":"2003","journal-title":"Pharmazie"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960859"},{"key":"e_1_2_1_8_1","first-page":"32","article-title":"New bianthraquinone pigments from Kniphofia species","volume":"1","author":"Dagne E","year":"1987","journal-title":"Bull Chem Soc Ethiop"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)83479-2"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033457494"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)86693-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9904915"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969529"},{"key":"e_1_2_1_14_1","first-page":"50","article-title":"Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture","volume":"33","author":"Ponnudurai T","year":"1981","journal-title":"Trop Geogr Med"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/415680a"},{"key":"e_1_2_1_16_1","volume-title":"Roll Back Malaria Infosheet","author":"World Health Organization","year":"2002"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T08:58:07Z","timestamp":1697101087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/ptr.1635"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1635","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}