{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T11:05:59Z","timestamp":1721559959066},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T00:00:00Z","timestamp":1141603200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Ondamtanggagambang<\/jats:italic> (ODG) has been used as a prescription for psychological anxiety and depression in Korean medicine. In this study, we found that ODG have protective effects against oxidative stress in cardiomyocytes. Pretreatment with ODG extract prevented H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> and ZnCl<jats:sub>2<\/jats:sub>\u2010induced cell damage in H9c2 cardiomyocytes, whereas simultaneous treatment of ODG extract did not. The protective effect of ODG extract on oxidative stress\u2010induced damage was suppressed significantly by heme oxygenase (HO) inhibitors, zinc protoporphyrin\u2010IX (ZnPP\u2010IX, <jats:italic>p<\/jats:italic> &lt; 0.01) and tin protoporphyrin\u2010IX (SnPP\u2010IX, <jats:italic>p<\/jats:italic> &lt; 0.01) in H9c2 cells. ODG stimulation of cells strongly induced the expression of HO\u20101 protein. Taken together, it is suggested that ODG\u2010induced expression of HO\u20101 may have a beneficial role in cardiomyocytes under oxidative stress. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1837","type":"journal-article","created":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T16:17:09Z","timestamp":1141661829000},"page":"235-236","source":"Crossref","is-referenced-by-count":10,"title":["Protective effects of Korean herbal remedy against oxidative stress in cardiomyocytes"],"prefix":"10.1002","volume":"20","author":[{"given":"Myung\u2010Sunny","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Young","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Jin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,6]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Dong\u2010Eui\u2010Bo\u2010Gam","author":"Huh J","year":"2002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00418-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.626"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450590521091"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.27.1.4862"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1837","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:52:01Z","timestamp":1700074321000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1002\/ptr.1837"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1837","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}