{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:29:03Z","timestamp":1785796143360,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T00:00:00Z","timestamp":1147132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracts of celery leaves and roots in ether, chloroform, ethyl acetate, <jats:italic>n<\/jats:italic>\u2010butanol and water were evaporated to dryness and dissolved in 50% ethanol to make 10% (w[sol ]v) solutions. The potential protective action of the extracts was assessed by the corresponding <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> tests. In the <jats:italic>in vitro<\/jats:italic> experiments crude methanol extracts were tested as potential scavengers of free OH<jats:sup>\u2022<\/jats:sup> and DPPH<jats:sup>\u2022<\/jats:sup> radicals, as well as inhibitors of liposomal peroxidation (LPx). Analogous experiments were also carried out with the extracts of celery root, for comparison. The results obtained show that both the extracts of root and leaves are good scavengers of OH<jats:sup>\u2022<\/jats:sup> and DPPH<jats:sup>\u2022<\/jats:sup> radicals and reduce LPx intensity in liposomes, which points to their protective (antioxidant) activity. <jats:italic>In vivo<\/jats:italic> experiments were concerned with antioxidant systems (activities of GSHPx, GSHR, Px, CAT, XOD, GSH content and intensity of LPx) in liver homogenate and blood of mice after their treatment with extracts of celery leaves, or in combination with CCl<jats:sub>4<\/jats:sub>. On the basis of the results obtained it can be concluded that the examined extracts showed a certain protective effect. Of all the extracts the <jats:italic>n<\/jats:italic>\u2010butanol extract showed the highest protective effect. Combined treatments with CCl<jats:sub>4<\/jats:sub> and extracts showed both positive and negative synergism \u2013 inducing or suppressing the impact of CCl<jats:sub>4<\/jats:sub> alone. The differences observed in the action of particular extracts are probably due to the different contents of flavonoids and some other antioxidant compounds. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1871","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T15:49:11Z","timestamp":1147189751000},"page":"531-537","source":"Crossref","is-referenced-by-count":71,"title":["Effect of celery (<i>Apium graveolens<\/i>) extracts on some biochemical parameters of oxidative Stress in mice treated with carbon 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