{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:04:06Z","timestamp":1754399046631},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T00:00:00Z","timestamp":1147392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antistress effects of BR\u201016A, a polyherbal preparation and its interaction with GABAergic modulators against social isolation\u2010induced stress were investigated in the present study. Isolation stress was induced by keeping the mice (Laca strain) individually in each cage for 3 weeks and various drug treatments were given for a period of 5 days before the start of the experiments. The various behavioural parameters examined included pentobarbitone\u2010induced sleep (sleep latency and duration), analgesia (tail\u2010\u00dfick test) and locomotor activity, respectively. BR\u201016A (100 mg\/kg and 200 mg\/kg) treatment for 5 days significantly reversed the social isolation stress\u2010induced prolongation of onset and decrease in pentobarbitone\u2010induced sleep, increased total motor activity and stress\u2010induced antinociception. When diazepam (0.5 mg\/kg), a benzodiazepine agonist, was co\u2010administered with BR\u201016A (100 mg\/kg), it significantly potentiated the reversal of pentobarbitone\u2010induced shortening of sleep time effects; increased locomotor activity and stress induced antinociceptive effects. However, the sleep latency was not decreased significantly. Further, \u00dfumazenil (2 mg\/kg), a benzodiazepine receptor antagonist and FG 7142 (10 mg\/kg), an inverse agonist, when co\u2010administered with BR\u201016A (100 mg\/kg), showed no significant reversal on pentobarbitone\u2010induced hypnosis, locomotor activity and social isolation\u2010induced antinociception compared with their effects <jats:italic>per se<\/jats:italic>. The present study demonstrated the antistress effects of BR\u201016A preparation against social isolation\u2010induced stress. The present study also suggests that the GABAergic system may be involved in its antistress effect. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1873","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T12:31:06Z","timestamp":1147437066000},"page":"538-541","source":"Crossref","is-referenced-by-count":11,"title":["Protective effect of BR\u201016A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism"],"prefix":"10.1002","volume":"20","author":[{"given":"Anil","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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