{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:59:00Z","timestamp":1761742740774},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T00:00:00Z","timestamp":1145318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the effects of ethanol extracts of <jats:italic>Butea superba<\/jats:italic> in increasing intracavernous pressure (ICP) <jats:italic>in vivo<\/jats:italic>. The extracts were prepared from fresh and dried root cores and fresh and dried root barks. Penile erection was induced in aged rats by electrical stimulation of the cavernous nerve. Cavernous smooth muscle relaxation was also observed <jats:italic>in vitro<\/jats:italic> in the presence of the extract, cGMP or isobutyl\u2010methylxanthine (IBMX) alone or the extract together with cGMP or IBMX. The dried root core extract from Phrae was the most effective in increasing the ICP. The dose\u2010response relationship study revealed a bell\u2010shape curve with the maximum effective dose at 1 mg\/kg. The ICP of the control and 1 mg\/kg extract\u2010treated animals were 45.3 \u00b1 2.5 and 100.9 \u00b1 14.0 mmHg, respectively. The extract, cGMP and IBMX alone induced dose dependent muscle relaxation. <jats:italic>B. superba<\/jats:italic> significantly enhanced the effects of cGMP and IBMX. The results suggest that ethanol extracts of <jats:italic>B. superba<\/jats:italic> are effective in enhancing penile erection. The dried root core extract from Phrae is the most effective part with a maximal dose of 1 mg\/kg. The results also suggest that <jats:italic>B. superba<\/jats:italic> may act through cAMP\/cGMP pathways. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1883","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T13:55:45Z","timestamp":1145368545000},"page":"484-489","source":"Crossref","is-referenced-by-count":16,"title":["<i>Butea superba<\/i> Roxb. enhances Penile erection in rats"],"prefix":"10.1002","volume":"20","author":[{"given":"Chainarong","family":"Tocharus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuthana","family":"Smitasiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rattima","family":"Jeenapongsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63299-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00621-0"},{"key":"e_1_2_1_4_1","volume-title":"Ya\u2010hoa\u2010Kwao\u2010Kreu\u2010Dang","author":"Loung\u2010Anusarnsoontorn","year":"1931"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-1051.1992.tb01311.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)40926-8"},{"key":"e_1_2_1_7_1","first-page":"169","article-title":"Flavonoid and flavonoid glycoside from Butea superba Roxb. and their cAMP phosphodiesterase inhibitory activity","volume":"25","author":"Roengsumran S","year":"2000","journal-title":"J Sci Res Chula"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900860"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286029808039856"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T03:00:14Z","timestamp":1696734014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,18]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1002\/ptr.1883"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1883","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,18]]}}}