{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:39:25Z","timestamp":1766266765767},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T00:00:00Z","timestamp":1146700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The antiinflammatory effect of the total flavonoids of <jats:italic>Laggera pterodonta<\/jats:italic> (TFLP) was evaluated with various <jats:italic>in vivo<\/jats:italic> models of both acute and chronic inflammation. In the acute inflammation tests, TFLP significantly inhibited xylene\u2010induced mouse ear oedema, carrageenan\u2010induced rat paw oedema and acetic acid\u2010induced mouse vascular permeability. In the carrageenan\u2010induced rat pleurisy model, TFLP efficiently suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the activity of serum superoxide dismutase (SOD), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) in the pleural exudates. No marked effect of TFLP on the activity of serum glutathione peroxidase (GSH\u2010PX) was observed. In the chronic inflammation experiment, TFLP inhibited cotton pellet\u2010induced rat granuloma. The antiinflammatory mechanisms of TFLP are probably associated with the inhibition of prostaglandin formation, influence on the antioxidant systems and the suppression of LZM release. The acute toxicity study revealed that TFLP was nontoxic in mice up to an oral dose of 7.5 g\/kg body weight. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1918","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T12:27:23Z","timestamp":1146745643000},"page":"585-590","source":"Crossref","is-referenced-by-count":35,"title":["Evaluation of antiinflammatory activity of the total flavonoids of <i>Laggera pterodonta<\/i> on acute and chronic inflammation 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