{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:55:39Z","timestamp":1784210139595,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T00:00:00Z","timestamp":1156809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of the ethanol extract of the rhizome of <jats:italic>Zingiber officinale<\/jats:italic> was tested against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) and acetaminophen\u2010induced liver toxicities in rats. Increases in serum and liver marker enzymes such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase as well as sorbitol and glutamate dehydrogenases were produced in normal rats that were not pretreated with the extract. However, extract\u2010pretreated rats attenuated in a dose\u2010dependent manner, CCl<jats:sub>4<\/jats:sub> and acetaminophen\u2010induced increases in the activities of ALT, AST, ALP, LDH and SDH in the blood serum. The protective effect of the extract on CCl<jats:sub>4<\/jats:sub> and acetaminophen\u2010induced damage was confirmed by histopathological examination of the liver. These results indicate that the oil from the rhizome of <jats:italic>Zingiber officinale<\/jats:italic> could be useful in preventing chemically induced acute liver injury. 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