{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:11:06Z","timestamp":1773904266203,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T00:00:00Z","timestamp":1152576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many studies have been carried out in recent years on the pharmacological effects of <jats:italic>nigella sativa<\/jats:italic> seeds that have uncovered their antiinflammatory and immunological effects. The objective of this study was to explore the antiinflammatory effects of thymoquinone on arthritis in rat models. Rats with arthritis induced by Freund's incomplete adjuvant were assigned into five groups: group 1: controls 0.9% NaCl (<jats:italic>n<\/jats:italic> = 7); group 2: 2.5 mg\/kg thymoquinone (<jats:italic>n<\/jats:italic> = 7); group 3: 5 mg\/kg thymoquinone (<jats:italic>n<\/jats:italic> = 7); group 4: Bacilli Chalmette Guerin (BCG) 6 \u00d7 10<jats:sup>5<\/jats:sup> CFU (<jats:italic>n<\/jats:italic> = 7); group 5: methotrexate 0.3 mg\/kg (<jats:italic>n<\/jats:italic> = 7). Signs of inflammation on the claw and radiological signs were searched for and TNF\u2010alpha and IL\u20101beta were measured. The results of control and other groups were compared. As a result, thymoquinone, confirmed clinically and radiologically, suppressed adjuvant\u2010induced arthritis in rats. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1964","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T16:16:43Z","timestamp":1152634603000},"page":"869-871","source":"Crossref","is-referenced-by-count":43,"title":["<i>Retracted<\/i>: Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models"],"prefix":"10.1002","volume":"20","author":[{"given":"Ibrahim","family":"Tekeoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Demiralp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00216-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1309"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1100266"},{"key":"e_1_2_1_5_1","first-page":"1227","article-title":"Studies on the Egyptian Nigella sativa L. Part IV: Some pharmacological properties of seeds' active principle in comparison to its dihydro compounds and its polymer","volume":"15","author":"El\u2010Dakhakhny M","year":"1965","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2005.8.488"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957994"},{"key":"e_1_2_1_8_1","first-page":"110","article-title":"A study of the antiinflammatory activity of Nigella sativa L. and thymoquinone in rats","volume":"5","author":"Mutabagani A","year":"1997","journal-title":"Saudi Pharmacol J"},{"key":"e_1_2_1_9_1","first-page":"627","volume-title":"Arthritis and Autoimmunity in Animals in Arthritis and Allied Conditions","author":"Philip L","year":"2005"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.06.008"},{"key":"e_1_2_1_11_1","first-page":"207","article-title":"Collagen\u2010induced arthritis as a model for rheumatoid arthritis","volume":"98","author":"Williams RO","year":"2004","journal-title":"Methods Mol Med"}],"updated-by":[{"DOI":"10.1002\/ptr.5312","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T00:00:00Z","timestamp":1425859200000},"record-id":"2371"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1964","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:37:12Z","timestamp":1696660632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,11]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/ptr.1964"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1964","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,11]]}}}