{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:32:02Z","timestamp":1790195522088,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,8,14]],"date-time":"2006-08-14T00:00:00Z","timestamp":1155513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Council of Scientific and Industrial Research, New Delhi","award":["9\/96(496)2K6-EMR-I"],"award-info":[{"award-number":["9\/96(496)2K6-EMR-I"]}]},{"name":"The University Grants Commission, New Delhi","award":["F.3-15\/ 2002\/SR-II"],"award-info":[{"award-number":["F.3-15\/ 2002\/SR-II"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Steroidal and non\u2010steroidal antiinflammatory drugs, despite their various side effects, are in great demand worldwide. Alternatively, herbal formulations provide relief to a large percentage of the population suffering from inflammatory diseases. Therefore, such practices need to be rationalized through a mechanistic approach. Thus, four traditional medicinal plants, namely <jats:italic>Ventilago madraspatana<\/jats:italic> Gaertn., <jats:italic>Rubia cordifolia<\/jats:italic> Linn., <jats:italic>Lantana camara<\/jats:italic> Linn. and <jats:italic>Morinda citrifolia<\/jats:italic> Linn. were selected for a study on the inhibition of nitric oxide (NO<jats:sup>\u2022<\/jats:sup>), a key mediator in the phenomenon of inflammation, signifying the presence of effective antiinflammatory constituents therein. Plant samples were extracted with different solvents for evaluation of their inhibitory activity on NO<jats:sup>\u2022<\/jats:sup> produced <jats:italic>in vitro<\/jats:italic> from sodium nitroprusside, and in LPS\u2010activated murine peritoneal macrophages, <jats:italic>ex vivo<\/jats:italic>. Further, the inhibition of NO<jats:sup>\u2022<\/jats:sup> synthesis was correlated with the reduction of iNOS protein expression through Western blot. Notable NO<jats:sup>\u2022<\/jats:sup> scavenging activity was exhibited <jats:italic>in vitro<\/jats:italic> by some extracts of <jats:italic>V. madraspatana<\/jats:italic>, <jats:italic>R. cordifolia<\/jats:italic> and <jats:italic>L. camara<\/jats:italic> (IC<jats:sub>50<\/jats:sub> &lt; 0.2 mg\/mL). Most of them showed marked inhibition (60%\u201380%), <jats:italic>ex vivo<\/jats:italic>, at a dose of 80 \u00b5g\/mL without appreciable cytotoxic effect on the cultured macrophages. Immunoblot analysis confirmed that the modulatory effect of the samples had occurred through suppression of iNOS protein. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.1971","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T11:10:58Z","timestamp":1155640258000},"page":"896-900","source":"Crossref","is-referenced-by-count":62,"title":["Evaluation of nitric oxide scavenging activity, <i>In Vitro<\/i> and <i>Ex Vivo<\/i>, of selected medicinal plants traditionally used in inflammatory diseases"],"prefix":"10.1002","volume":"20","author":[{"given":"Subhalakshmi","family":"Basu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banasri","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1752"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03913-H"},{"key":"e_1_2_1_4_1","volume-title":"The Treatise on Indian Medicinal Plants","author":"Chatterjee A","year":"1997"},{"key":"e_1_2_1_5_1","volume-title":"Glossary of Indian Medicinal Plants","author":"Chopra RN","year":"1956"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020398"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04068.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1764"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31375-9"},{"key":"e_1_2_1_11_1","first-page":"76","article-title":"Preliminary investigation of the anti\u2010inflammatory properties of an aqueous extract from Morinda citrifolia (Noni)","volume":"45","author":"McKoy ML","year":"2002","journal-title":"Proc West Pharmacol Soc"},{"key":"e_1_2_1_12_1","volume-title":"Herbal Medicinals: A Clinician's Guide","author":"Miller LG","year":"2005"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292706"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000200023"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36703-0"},{"key":"e_1_2_1_16_1","volume-title":"Medicinal Plants of the World \u2013 Chemical Constituents, Traditional and Modern Medicinal Uses.","author":"Ross IA","year":"1999"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(00)00181-7"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048286"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.1971","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.1971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:36:54Z","timestamp":1696660614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.1971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,14]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/ptr.1971"],"URL":"https:\/\/doi.org\/10.1002\/ptr.1971","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,14]]}}}