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In a radioligand binding assay for A<jats:sub>1<\/jats:sub>adenosine receptor occupancy in particulate preparations from guinea\u2010pig cerebral cortex, flavonoids competed in concentration\u2010dependent manners with Hill slopes typically not different from unity. Of the \ufb02avonoids tested, quercetin showed highest affinity (pK<jats:italic>i<\/jats:italic>value of 5.33). At a concentration of 28 mm, quercetin evoked a rightward shift in the<jats:italic>N<\/jats:italic><jats:sup>6<\/jats:sup>\u2010cyclopentyladenosine\u2010induced inhibition of electrically evoked contractions of the guinea\u2010pig isolated ileum, allowing the calculation of a pK<jats:sub>i<\/jats:sub>value of 4.71. These data suggest, therefore, that \ufb02avonoids represent an additional dietary source of A<jats:sub>1<\/jats:sub>adenosine receptor antagonists (beyond the methylxanthines, caffeine and theophylline). 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