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Chickens orally administered SCE or PRF (500 mg\/kg\/day) for 3 consecutive days showed significantly higher antibody responses against sheep red blood cells and <jats:italic>Brucella abortus<\/jats:italic> than control chickens. In addition, oral administration of SCE or PRF also resulted in a significant increase in the number of IgM\u2010 and IgG\u2010plaque forming cell responses of PBL, intestinal leukocytes and splenocytes, when compared with those of control chickens. Furthermore, delayed type hypersensitivity responses to human <jats:italic>\u03b3<\/jats:italic> globulin significantly increased in chickens orally administered SCE or PRF, compared with those of control chickens when evaluated on the basis of net increased wattle thickness at 24, 48 and 72 h after challenge. These results suggest that PRF of SCE has an immunostimulating effect in chickens. 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