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The crude dichloromethane:chloroform extract of <jats:italic>Stypopodium zonale<\/jats:italic> showed good cytotoxic activity against the C32 cell line. The crude acetone extract and aqueous phase of <jats:italic>Lobophora variegata<\/jats:italic> did not show any activity, but semi\u2010purified fractions XAD LOB I and II could inhibit the growth of melanoma cells. The crude acetone extract of <jats:italic>Caulerpa racemosa<\/jats:italic> showed some cytotoxicity, but caulerpin isolated from this extract did not show any such activity. The crude acetone extract of <jats:italic>Spatoglossum schroederi<\/jats:italic> was not able to inhibit the growth of C32 melanoma cells. 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