{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:42:11Z","timestamp":1773279731712,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated a new herbal preparation, HemoHIM, for its antiinflammatory activity against carrageenan\u2010induced edema, the formation of granulation tissues by cotton pellet and experimental colitis by 2,4,6\u2010trinitrobenzene sulfonic acid (TNBS). The HemoHIM was prepared by adding its ethanol\u2010insoluble polysaccharide fraction to the total water extract of Angelica Radix, Cnidii Rhizoma and Paeonia Radix. The preparation (4 mg of solids\/mL of drinking water, p.o., 50\u2013100 mg\/kg of body weight, i.p.) produced a dose\u2010related inhibition of carrageenan\u2010induced paw edema and cotton pellet\u2010induced granuloma in rats. In addition, HemoHIM also reduced the degree of TNBS\u2010induced colitis and improved the gross and histological changes such as thickening, dilatation, ulceration, and infiltration by polymorphonuclear leukocytes and multiple erosive lesions. These results demonstrate that the HemoHIM has a potent antiinflammatory effect. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2068","type":"journal-article","created":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T10:48:02Z","timestamp":1178621282000},"page":"625-628","source":"Crossref","is-referenced-by-count":16,"title":["Antiinflammatory activity of an herbal preparation (HemoHIM) in rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Sung Kee","family":"Jo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae June","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Ra","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Choon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Sik","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uhee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Ran","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Sik","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8552"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.884"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1175"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1972.tb08940.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711040103"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1383"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00399-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(96)01523-1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3746\/jkfn.2005.34.6.805"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri915"},{"key":"e_1_2_1_12_1","first-page":"529","article-title":"The protective effects of radix astragali and rhizoma ligustici chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria","volume":"36","author":"Lu ZM","year":"2005","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3746\/jfn.2006.11.1.054"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.3746\/jkfn.2005.34.5.605"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2004.03.005"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.100301.064816"},{"key":"e_1_2_1_17_1","first-page":"226","article-title":"Phases of inflammatory response to subcutaneous implantation of cotton pellet and other modifications by certain anti\u2010inflammatory agents","volume":"183","author":"Swingle KF","year":"1972","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1139\/y88-071"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:26:21Z","timestamp":1700051181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,8]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/ptr.2068"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2068","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,8]]}}}