{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:34:20Z","timestamp":1791466460398,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T00:00:00Z","timestamp":1196899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine the mechanism underlying the hypoglycaemic activity of the aqueous extract perfusion of <jats:italic>Lepidium sativum<\/jats:italic> L. (LS) in normal and streptozotocin\u2010induced diabetic rats. The aqueous LS extract was administered intravenously and the blood glucose levels were determined within 4 h of treatment. Plasma insulin concentrations and glycosuria were determined. The 24 h urinary transforming growth factor\u2010<jats:italic>\u03b2<\/jats:italic>1 (ELISA) was evaluated in diabetic and control rats 15 days after oral treatment with the aqueous LS extract at a dose of 20 mg\/kg.<\/jats:p><jats:p>The study showed that LS at a dose of 10 mg\/kg\/h reduced blood glucose levels both in normal and diabetic rats (<jats:italic>p<\/jats:italic> &lt; 0.001). At the same time as a potent increase of glycosuria was observed both in normal and diabetic rats (<jats:italic>p<\/jats:italic> &lt; 0.001). In addition, oral administration of LS for 15 days normalized glycaemia (<jats:italic>p<\/jats:italic> &lt; 0.001), enhanced glycosuria (<jats:italic>p<\/jats:italic> &lt; 0.05 vs diabetic control) and decreased the amount of urinary TGF\u2010<jats:italic>\u03b2<\/jats:italic>1 (<jats:italic>p<\/jats:italic> &lt; 0.01) in diabetic rats.<\/jats:p><jats:p>It is concluded that the aqueous LS extract caused a potent inhibition of renal glucose reabsorption which in turn reduced blood sugar. This renal effect is at least one mechanism explaining the observed hypoglycaemic activity of this plant in normal and diabetic rats. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2101","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T20:21:11Z","timestamp":1196972471000},"page":"1-5","source":"Crossref","is-referenced-by-count":21,"title":["Effect of <i>Lepidium sativum<\/i> L. on renal glucose reabsorption and urinary TGF\u2010<i>\u03b2<\/i>1 levels in diabetic rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Mohamed","family":"Eddouks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhamed","family":"Maghrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00206-9"},{"key":"e_1_2_1_3_1","first-page":"555","article-title":"Prevalence of diabetes and hypertension in a rural population of Bangladesh","volume":"4","author":"Abutt SM","year":"1995","journal-title":"Diabetes Care"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000189300"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.267"},{"key":"e_1_2_1_6_1","first-page":"90","volume-title":"Textbook of Nephrology","author":"Deetjen P","year":"1995"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.05.005"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00164-2"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.030"},{"key":"e_1_2_1_10_1","first-page":"285","article-title":"Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene\u2010induced DNA damage: a model study with the single cell gel electrophoresis\/Hep G2 assay","volume":"3","author":"Fekadu K","year":"2003","journal-title":"Chem Biol Interact"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2337\/diab.37.12.1608","article-title":"Glucose counterregulation and its impact on diabetes mellitus","volume":"12","author":"Gerich JE","year":"1988","journal-title":"Diabetes"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.2337\/diab.46.12.2110","article-title":"Improved glucose tolerance restores insulin\u2010stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto\u2010Kakizaki rats","volume":"12","author":"Krook A","year":"1997","journal-title":"Diabetes"},{"issue":"1","key":"e_1_2_1_13_1","first-page":"44","article-title":"Lipoprotein lipase in experimental diabetic rats: beneficial effect of vanadate treatment","volume":"17","author":"Levy E","year":"1991","journal-title":"Diabete Metab"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1627"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(98)00275-1"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.9.2061"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00016-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18683"},{"key":"e_1_2_1_19_1","first-page":"2017","volume-title":"Handbook of Physiology","author":"Silverman M","year":"1992"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T11:51:53Z","timestamp":1700049113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,6]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/ptr.2101"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2101","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,6]]}}}