{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:31:30Z","timestamp":1759530690547},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>2,5\u2010Dihydroxy\u20104,3\u2032\u2010di(<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyloxy)\u2010<jats:italic>trans<\/jats:italic>\u2010stilbene was identified from <jats:italic>Morus bombycis<\/jats:italic> Koidzumi roots. The 2,5\u2010dihydroxy\u20104,3\u2032\u2010di(<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyloxy)\u2010<jats:italic>trans<\/jats:italic>\u2010stilbene at a dose of 400\u2013600 mg\/kg had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5\u2010dihydroxy\u20104,3\u2032\u2010di(<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyloxy)\u2010<jats:italic>trans<\/jats:italic>\u2010stilbene from <jats:italic>Morus bombycis<\/jats:italic> Koidzumi roots decreased cell ballooning in response to CCl<jats:sub>4<\/jats:sub> treatment. These results demonstrate that the 2,5\u2010dihydroxy\u20104,3\u2032\u2010di(<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyloxy)\u2010<jats:italic>trans<\/jats:italic>\u2010stilbene component has a liver protective action against CCl<jats:sub>4<\/jats:sub>\u2010induced hepatotoxicity. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2121","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T13:09:48Z","timestamp":1173877788000},"page":"605-608","source":"Crossref","is-referenced-by-count":8,"title":["Identification and properties of 2,5\u2010Dihydroxy\u20104,3\u2032\u2010di(<i>\u03b2<\/i>\u2010<scp>d<\/scp>\u2010glucopyranosyloxy)\u2010<i>trans<\/i>\u2010stilbene from <i>Morus bombycis<\/i> Koidzumi roots"],"prefix":"10.1002","volume":"21","author":[{"given":"Ying\u2010Shan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Kyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010II","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong\u2010Hyeon","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050735"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90102-0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00298-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.2.1537462"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)00122-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650070603"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/S0021-9258(17)43327-8","article-title":"Oxygen\u2010 and carbon\u2010centered free radical formation during carbon tetrachloride metabolism","volume":"259","author":"McCay PB","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_1","first-page":"395","article-title":"Thiobarbituric acid value on fresh homogenate of rats as a parameter of lipid peroxidation in aging, CCl4 intoxication, and vitamin E deficiency","volume":"7","author":"Mihara M","year":"1980","journal-title":"Biochem Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408449309104072"},{"key":"e_1_2_1_12_1","volume-title":"Handbook of Free Radicals and Antioxidants in Biomedicine","author":"Recknagel RO","year":"1989"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2220001"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11830"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050438"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8547"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/clinchem\/33.2.214","article-title":"Lipoperoxide in plasma as measured by liquid\u2010chromatographic separation of malondialdehyde\u2010thiobarbituric acid adduct","volume":"33","author":"Wong SH","year":"1987","journal-title":"Clin Chem"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957387"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.1.139"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:26:36Z","timestamp":1700051196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,14]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/ptr.2121"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2121","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,14]]}}}