{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:19:31Z","timestamp":1759529971770},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of a diterpenoid isolated from <jats:italic>Salvia cinnabarina<\/jats:italic>, 3,4\u2010seicosopimar\u20104(18),7,15\u2010triene\u20103\u2010oic acid (SCB), on arterial blood pressure was evaluated in anaesthetized rats.<\/jats:p><jats:p> Male Wistar rats, anaesthetized with urethane (sol. 10% p\/v; 10 mL\/kg), underwent surgery for continuous monitoring of arterial blood pressure. After preliminary experiments to evaluate the dose response (3, 10 and 30 mg\/kg i.v.) of SCB, a dose of 3 mg\/kg was chosen for all successive experiments. On different groups of rats treated with the ganglion\u2010blocking agent chlorisondamine (2.5 mg\/kg i.p.) the effect of SCB (3 mg\/kg i.v.) was evaluated before and following an infusion of the nitric oxide synthase inhibitor <jats:sc>l<\/jats:sc>\u2010NAME (0.3 mg\/kg\/min i.v.). Intravenous administration of SCB at doses of 3, 10 and 30 mg\/kg led to a fall in mean arterial blood pressure (MABP) of 14.75 \u00b1 1.44 mmHg, 36.60 \u00b1 31.40 mmHg and 31.40 \u00b1 6.28 mmHg, respectively (<jats:italic>n<\/jats:italic> = 4\u20135), that was not modified by treatment of the rat with chlorisondamine nor with <jats:sc>l<\/jats:sc>\u2010NAME. The results demonstrate a hypotensive effect of SCB \u2013 due to a peripheral mechanism but independent of endothelial nitric oxide release. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2128","type":"journal-article","created":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T13:15:32Z","timestamp":1173878132000},"page":"690-692","source":"Crossref","is-referenced-by-count":12,"title":["Effect of a diterpenoid from <i>Salvia cinnabarina<\/i> on arterial blood pressure in rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Alessio","family":"Alfieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Bisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Romussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Mascolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Cicala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00396-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(1998)12:1 <S117::AID-PTR269>3.0.CO;2-2"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-818954"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815501"},{"key":"e_1_2_1_6_1","first-page":"686","article-title":"Antimicrobial substances of Salvia officinalis","volume":"5","author":"Dobrynin VN","year":"1976","journal-title":"Khim Prip Soedin"},{"key":"e_1_2_1_7_1","volume-title":"Repertorium Specierum Novarum Regni Vegetabilis: A revision of Salvia, subgenus Calosphace","author":"Epling C","year":"1939"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960830"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-11511"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:27:18Z","timestamp":1700051238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,14]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1002\/ptr.2128"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2128","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,14]]}}}