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A single oral dose of CCl<jats:sub>4<\/jats:sub> (1.25 mL\/kg) produced significantly increased levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities. In addition, increased malondialdehyde (MDA) concentration, reduced glutathione (GSH) content, and decreased catalase, superoxide dismutase (SOD) and glutathione\u2010S\u2010transferase (GST) activities were observed in the hepatic tissues. However, concomitant administration with PYC (10 or 20 mg\/kg) significantly improved CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic injury, as evidenced by the decline of serum AST and ALT activities in a dose dependent manner. Moreover, PYC reduced MDA concentration and increased GSH levels and catalase, SOD and GST activities in hepatic tissues, indicating that concomitant administration with PYC efficiently prevent the CCl<jats:sub>4<\/jats:sub>\u2010induced oxidative damage in rats. The free radical scavenging assay showed that PYC has a dose\u2010dependent scavenging activity against 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) free radicals. These results indicate that PYC has an antioxidant effect against CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic oxidative damage and is useful as a hepatoprotective agent against various liver diseases induced by oxidative stress. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2146","type":"journal-article","created":{"date-parts":[[2007,9,20]],"date-time":"2007-09-20T12:52:57Z","timestamp":1190292777000},"page":"1015-1019","source":"Crossref","is-referenced-by-count":34,"title":["Ameliorative effects of pycnogenol<sup>\u00ae<\/sup> on carbon tetrachloride\u2010induced hepatic oxidative damage in 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