{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:10:49Z","timestamp":1790673049886,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper describes the screening of different South American plant extracts and fractions. Aqueous and organic extracts were prepared and tested for antiherpetic (HSV\u20101, KOS and 29R strains) and antirabies (PV strain) activities. The evaluation of the potential antiviral activity of these extracts was performed by using an MTT assay for HSV\u20101, and by a viral cytopathic effect (CPE) inhibitory method for rabies virus (RV). The results were expressed as 50% cytotoxicity (CC<jats:sub>50<\/jats:sub>) for MTT assay and 50% effective (EC<jats:sub>50<\/jats:sub>) concentrations for CPE, and with them it was possible to calculate the selectivity indices (SI = CC<jats:sub>50<\/jats:sub>\/EC<jats:sub>50<\/jats:sub>) of each tested material. From the 18 extracts\/fractions tested, six extracts and four fractions showed antiviral action.<jats:italic>Ilex paraguariensis, Lafoensia pacari, Passiflora edulis, Rubus imperialis<\/jats:italic>and<jats:italic>Slonea guianensis<\/jats:italic>showed values of SI &gt; 7 against HSV\u20101 KOS and 29\u2010R strains and<jats:italic>Alamanda schottii<\/jats:italic>showed a SI of 5.6 against RV, PV strain. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2198","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T16:56:17Z","timestamp":1183136177000},"page":"970-974","source":"Crossref","is-referenced-by-count":58,"title":["Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus"],"prefix":"10.1002","volume":"21","author":[{"given":"Vanessa","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana H.","family":"Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio H.","family":"Reginatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana M.","family":"Zucolotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionezine","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosendo A.","family":"Yunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloir P.","family":"Schenkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia R. 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