{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T16:40:28Z","timestamp":1737304828740,"version":"3.33.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T00:00:00Z","timestamp":1184716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Affairs of Kerman University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Considering the high consumption rate of marjoram in the Iranian population, this study was designed to investigate the effects of marjoram extract on gastric acid and pepsin secretion. In this study, Wistar rats (<jats:italic>n<\/jats:italic>= 12) were divided into two equal case and control groups. Under general anaesthesia with 50 mg\/kg i.p. sodium thiopental, laparatomy was done and a cannula inserted in the duodenum. In the case animals marjoram (12.5 mg\/kg) was injected into the stomach through the mentioned cannula. The gastric contents were collected by the wash\u2010out technique. Acid and pepsin secretions were then measured by titration and the Anson method, respectively. In the marjoram group, basal acid and pepsin secretions were significantly increased compared with the control group (acid: 20 \u00b1 3.36 vs 4.1 \u00b1 0.36 \u00b5mol\/15 min; pepsin: 9.04 \u00b1 0.01 vs 5.62 \u00b1 0.12 \u00b5g\/15 min;<jats:italic>p<\/jats:italic>&lt; 0.001). In the control group, pentagastrin stimulation increased acid secretion in comparison with the basal level (10.14 \u00b1 1.34 vs 4.1 \u00b1 0.36 \u00b5mol\/15 min,<jats:italic>p<\/jats:italic>&lt; 0.001), while in the marjoram group, there was a significant decline (16.46 \u00b1 3.23 vs 20 \u00b1 3.36 \u00b5mol\/15 min,<jats:italic>p<\/jats:italic>&lt; 0.001). In the marjoram group pentagastrin increased pepsin secretion in comparison with the basal state (12 \u00b1 0.11 vs 9.04 \u00b1 0.1 \u00b5g\/15 min,<jats:italic>p<\/jats:italic>&lt; 0.001). It seems that marjoram contains some components that activate chief and parietal cells and increase basal acid and pepsin secretion. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2203","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T10:22:34Z","timestamp":1184754154000},"page":"1036-1038","source":"Crossref","is-referenced-by-count":3,"title":["Marjoram increases basal gastric acid and pepsin secretions in rat"],"prefix":"10.1002","volume":"21","author":[{"given":"Fatemeh Nabavizadeh","family":"Rafsanjani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Shahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakieh Vahedian","family":"Ardakani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Vahedian","family":"Ardakani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"576","volume-title":"Physiology","author":"Berne RM","year":"2003"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/00365521.1970.12096601","article-title":"A modified hemoglobin substrate method for the estimation of pepsin in gastric juice","volume":"5","author":"Berstad A","year":"1970","journal-title":"Scand J Gastroenterol"},{"issue":"146","key":"e_1_2_1_4_1","first-page":"22","article-title":"Regulation of receptors on parietal cells on acid secretion","volume":"23","author":"Bertaccine G","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1990.tb06559.x"},{"key":"e_1_2_1_6_1","first-page":"371","article-title":"Effects of hypoxic 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stimulates gastric acid secretion through a vagal mechanism in rats","volume":"269","author":"McTigue DM","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_14_1","first-page":"1356","article-title":"The effects of chronic consumption of heroin on basal and vagal electrical\u2010stimulated gastric acid and pepsin secretion in rat","volume":"25","author":"Nabavizadeh FR","year":"2004","journal-title":"Saudi Med J"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.02.017"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.33549\/physiolres.930012","article-title":"Calcium, carbonic anhydrase and gastric secretion","volume":"50","author":"Puscas I","year":"2001","journal-title":"Physiol Res"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000199607"},{"key":"e_1_2_1_18_1","first-page":"G987","article-title":"Substrate P in the dorsal vagal complex inhibit medullary TRH\u2010induced gastric acid 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