{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:42:21Z","timestamp":1781271741115,"version":"3.54.1"},"reference-count":7,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T00:00:00Z","timestamp":1184716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase\u20101 and \u20102.<\/jats:p><jats:p>Water, methanol, dichloromethane and hexane extracts of rose hip were tested for <jats:italic>in vitro<\/jats:italic> COX\u20101 and 2 activity.<\/jats:p><jats:p>The organic solvent extracts showed good inhibition of both COX\u20101 and 2. The methanol extract was most active in both assays with IC<jats:sub>50<\/jats:sub> values of 12 \u00b5g\/mL for COX\u20101 and 19 \u00b5g\/mL for COX\u20102.<\/jats:p><jats:p>The clinically observed effect might be due to inhibition of cyclooxygenase. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2236","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T10:19:21Z","timestamp":1184753961000},"page":"1251-1252","source":"Crossref","is-referenced-by-count":51,"title":["COX\u20101 and \u20102 activity of rose hip"],"prefix":"10.1002","volume":"21","author":[{"given":"A. K.","family":"J\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.S.","family":"Eldeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"van Staden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1729"},{"key":"e_1_2_1_3_1","volume-title":"Gigtforeningens Sp\u00f8rgeskemaunders\u00f8gelse Blandt Reumatologisk Patienter Vedr\u00f8rende Alternativ Behandling.","author":"Gigtforeningen","year":"2003"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(96)01395-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0300636"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199703)11:2<113::AID-PTR27>3.0.CO;2-S"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(95)01285-L"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00183-5"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:47:07Z","timestamp":1699994827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,18]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1002\/ptr.2236"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2236","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,18]]}}}