{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T22:35:42Z","timestamp":1720218942906},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T00:00:00Z","timestamp":1185494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Bergenia ciliata<\/jats:italic> is used for the treatment of stomach disorders in the folk medicine of some areas of South East Asia. This study was designed to evaluate its gastroprotective effects on ethanol\/HCl, indomethacin and pylorus ligation\u2010induced gastric ulcers in rats. Doses of 15, 30 and 60 mg\/kg b\/w of the aqueous and methanol extracts of the rhizome were administered 1 h after ulcerogenic treatment. The animals were killed 3 h later, their stomachs removed and the mean area of ulcer lesion was determined. The weight of mucus and gastric acidity were also measured. The aqueous extract decreased the ulcer lesion (<jats:italic>p<\/jats:italic> &lt; 0.05) in all models to a greater extent than the methanol extract, but at the higher doses the effect was reduced. In addition, the antiulcer activity appears to be mediated via cytoprotective effects conferred by enhancement of the mucosal barrier, rather than by prevention of gastric acid secretion or the lowering of pH and acidity. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2242","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T15:46:42Z","timestamp":1185551202000},"page":"1217-1220","source":"Crossref","is-referenced-by-count":12,"title":["Cytoprotective effects of <i>Bergenia ciliata<\/i> Sternb, extract on gastric ulcer in rats"],"prefix":"10.1002","volume":"21","author":[{"given":"G.","family":"Kakub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gulfraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00092-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959654"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1254\/fpj.85.443"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(96)01488-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1078\/0944-7113-00017"},{"key":"e_1_2_1_7_1","first-page":"15","article-title":"Bioactivity evaluation of Bergenia ciliata","volume":"15","author":"Islam M","year":"2002","journal-title":"Pak J Pharm Sci"},{"key":"e_1_2_1_8_1","first-page":"99","article-title":"A simplified method for evaluating dose\u2010effect experiments","volume":"96","author":"Litchfield JT","year":"1949","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1975.tb07351.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130070032"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.23.595"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(00)00303-8"},{"key":"e_1_2_1_13_1","first-page":"849","article-title":"The relationship between titrated acidity (mEq\/l) and pH of human gastric juice: a study based on the data estimated by pH\u2010meter","volume":"91","author":"Segawa K","year":"1994","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-3-368"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1076\/1388-0209(200004)3821-1FT112","article-title":"Antiulcer activity of the crude extract from the leaves of casearia sylvestris","volume":"38","author":"Sertie JAA","year":"2000","journal-title":"Pharmac Biol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357011775398"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(96)01461-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(00)80037-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00142-3"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb07522.x"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:46:07Z","timestamp":1699994767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,27]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1002\/ptr.2242"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2242","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,27]]}}}