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CCl<jats:sub>4<\/jats:sub> (5%; 0.1 mL\/10 g body weight) was given twice a week for 9 weeks, and mice received AFEF throughout the whole experimental period. Plasma GPT, hepatic levels of hydroxyproline and malondialdehyde were significantly lower in mice treated with AFEF compared with those treated with CCl<jats:sub>4<\/jats:sub> only. Liver pathology in the AFEF\u2010treated mice was also improved. RT\u2010PCR analysis showed that AFEF treatment increased the expression of <jats:italic>methionine adenosyltransferase 1A<\/jats:italic> and decreased the expression of <jats:italic>collagen(\u03b11)(I)<\/jats:italic> and <jats:italic>transforming growth factor\u2010\u03b21.<\/jats:italic> These results clearly demonstrated that AFEF reduced the hepatic damage induced by CCl<jats:sub>4<\/jats:sub> in mice. 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