{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:05:47Z","timestamp":1787731547895,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T00:00:00Z","timestamp":1191888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne is a typical condition of adolescence and is caused by multi\u2010factorial events including hormonal, microbiological and immunological mechanisms. Although there has been much debate about the direct involvement of bacteria, <jats:italic>Propionibacterium acnes<\/jats:italic> is now believed to contribute to the inflammatory stages of the condition, and thus initiate the inflamed lesion. The present study examined the anti\u2010acne properties of the <jats:italic>Selaginella involvens<\/jats:italic> extract (SIE) in cell models. Primarily, SIE was not found to be cytotoxic under 50 \u00b5g\/mL, and revealed the inhibitory effect on both nitric oxide (NO) production and iNOS\/IL\u20101<jats:italic>\u03b2<\/jats:italic> expression as well as the NO scavenging effect. The IL\u20101<jats:italic>\u03b1<\/jats:italic> and IL\u20108 cytokines, triggering the inflammatory acne response, were also inhibited in keratinocytes when stimulated with viable <jats:italic>P. acnes<\/jats:italic>. Furthermore, SIE was found to have an antioxidant effect in a dose\u2010dependent manner in the hydroxyl radical\u2010mediated oxidation test. Finally, it was found that SIE has non\u2010antibiotic antimicrobial activity at a dose greater than 100 \u00b5g\/mL on <jats:italic>P. acnes<\/jats:italic>. In conclusion, SIE may be a safe non\u2010antibiotic anti\u2010acne source in the therapeutic application of the treatment of acne development by reducing the chance of non\u2010specific initiation and augmentation phase of the inflammatory response. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2319","type":"journal-article","created":{"date-parts":[[2007,10,9]],"date-time":"2007-10-09T17:30:38Z","timestamp":1191951038000},"page":"335-339","source":"Crossref","is-referenced-by-count":18,"title":["Anti\u2010acne activity of <i>Selaginella involvens<\/i> extract and its non\u2010antibiotic antimicrobial potential on <i>Propionibacterium acnes<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Seong Soo","family":"Joo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Kil","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Geun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Seok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Woo","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Ik","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017876"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01540.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2001.01292.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00751.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X05003442"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2133.1996.d01-733.x","article-title":"The effects of acne treatment with a combination of benzoyl peroxide and erythromycin on skin carriage of erythromycin\u2010resistant propionibacteria","volume":"134","author":"Eady EA","year":"1996","journal-title":"Br J Dermatol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.006"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.19075"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05762.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05749.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650050412"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(02)00527-5"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06530.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.9.2.179"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017875"},{"key":"e_1_2_1_19_1","first-page":"4","article-title":"The pathophysiology of acne","volume":"76","author":"Webster GF","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.10.010"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:56:29Z","timestamp":1699973789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/ptr.2319"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2319","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,9]]}}}