{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:00:31Z","timestamp":1791126031894,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Extracts from the Andean lichens\n                    <jats:italic>Protousnea poeppigii<\/jats:italic>\n                    and\n                    <jats:italic>Usnea florida<\/jats:italic>\n                    displayed antimicrobial activity against the pathogenic fungi\n                    <jats:italic>Microsporum gypseum<\/jats:italic>\n                    ,\n                    <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>T. rubrum<\/jats:italic>\n                    with MIC values between 50 and 100 \u00b5g\/mL. From the active extracts, four main metabolites were isolated and identified as the new depside, isodivaricatic acid, and the known metabolites 5\u2010propylresorcinol, divaricatinic acid and usnic acid. Isodivaricatic acid and divaricatinic acid presented antifungal effect towards\n                    <jats:italic>M. gypseum<\/jats:italic>\n                    with a MIC of 50 \u00b5g\/mL and against\n                    <jats:italic>T. mentagrophytes<\/jats:italic>\n                    and\n                    <jats:italic>T. rubrum<\/jats:italic>\n                    and with MIC values of 50 and 100 \u00b5g\/mL, respectively. The new isodivaricatic acid was active towards\n                    <jats:italic>Leishmania amazonensis<\/jats:italic>\n                    ,\n                    <jats:italic>Leishmania brasiliensis<\/jats:italic>\n                    and\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    promastigotes with 100% lysis at 100 \u00b5g\/mL.\n                  <\/jats:p>\n                  <jats:p>The activity of the new compound decreased on acetylation of the hydroxy groups as well as on methylation of the acid function. The structures were elucidated by spectroscopic means. The spectroscopic data of isodivaricatic acid are presented here for the first time. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2321","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T08:18:59Z","timestamp":1196756339000},"page":"349-355","source":"Crossref","is-referenced-by-count":66,"title":["A new antifungal and antiprotozoal depside from the andean lichen\n                    <i>Protousnea poeppigii<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Guillermo","family":"Schmeda\u2010Hirschmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Pertino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Sortino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Zacchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta Rojas de","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Egly","family":"Feresin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02027793"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b203399b"},{"key":"e_1_2_1_4_1","first-page":"493","article-title":"Study of the cytotoxic and antimicrobial activities of usnic acid and derivatives","volume":"69","author":"Correche ER","year":"1998","journal-title":"Fitoterapia"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)85190-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00453-9"},{"key":"e_1_2_1_7_1","unstructured":"Dictionary of Natural Products on CDROM 2007 Chapman and Hall\/CRC Boca Raton FL"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.04165.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/C97091"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-006-0208-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0742-8413(96)00127-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961433"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89571-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(80)87031-2"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00383-7"},{"key":"e_1_2_1_16_1","first-page":"1526","volume-title":"Manual of Clinical Microbiology","author":"Jorgensen JH","year":"1999"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(98)00181-0"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cad.0000175588.09070.77"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(93)80057-Y"},{"key":"e_1_2_1_20_1","first-page":"8","volume-title":"El Uso Medicinal y Alimenticio de Plantas Nativas y Naturalizadas en Chile","author":"Mu\u00f1oz M","year":"1981"},{"key":"e_1_2_1_21_1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing; Ninth Informational Supplement","author":"National Committee for Clinical and Laboratory Standards (NCCLS)","year":"1999"},{"key":"e_1_2_1_22_1","first-page":"1","volume-title":"Method M\u201027\u2010A2 for Yeasts","author":"National Committee for Clinical and Laboratory Standards (NCCLS)","year":"2002"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.3.860-869.2003"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.043"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-958027"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0366-16442002000300006"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0600595"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(98)00033-1"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2005.12.001"},{"key":"e_1_2_1_30_1","unstructured":"The Pherobase. 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