{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:57:53Z","timestamp":1791219473870,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T00:00:00Z","timestamp":1196726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the present study was to investigate the effects of the Chinese medical herb Astragali Radix on myocardial injury <jats:italic>in vivo<\/jats:italic> and its possible mechanisms. Myocardial injury in rats was induced by the subcutaneous injection of a high dose of isoproterenol for 10 days, and the therapeutic effects of Astragali Radix were observed. Cardiac hemodynamics, heart coefficient and marker enzymes in serum showed that Astragali Radix prevented isoproterenol\u2010induced myocardial damage. Astragali Radix also improved the antioxidant status by decreasing the lipid peroxidative product malondialdehyde and increasing the activity of the antioxidant enzyme superoxide dismutase. The observed depressions in sarcoplasmic reticulum Ca<jats:sup>2+<\/jats:sup>\u2010ATPase mRNA and protein expression as well as Ser<jats:sup>16<\/jats:sup>\u2010phosphorylated phospholamban protein expression in isoproterenol\u2010treated rats were attenuated by Astragali Radix treatment. Moreover, treatment with Astragali Radix showed higher myocardial cAMP content compared with the isoproterenol\u2010alone group. These results suggest that the antioxidant property and partial prevention of changes in protein and gene expression of cardiac sarcoplasmic reticulum Ca<jats:sup>2+<\/jats:sup> regulatory proteins which may be mediated through the cAMP pathway could help to explain the beneficial effects of Astragali Radix on myocardial injury <jats:italic>in vivo<\/jats:italic>. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2332","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T13:19:34Z","timestamp":1196774374000},"page":"389-394","source":"Crossref","is-referenced-by-count":38,"title":["Cardioprotective effects of Astragali Radix against isoproterenol\u2010induced myocardial injury in rats and its possible mechanism"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiao\u2010Le","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Yi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu\u2010Ju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.04.009"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(81)90040-X"},{"key":"e_1_2_1_4_1","first-page":"141","article-title":"Effects of Astragalus membranaceus on left ventricular function and oxygen free radical in acute myocardial infarction patients and mechanism of its cardiotonic action","volume":"15","author":"Chen LX","year":"1995","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X06004028"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003950200033"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00212-5"},{"key":"e_1_2_1_8_1","first-page":"234","article-title":"Progress of experimental pharmacologic study on the effect of Astragalus on the cardiac vascular system","volume":"20","author":"Han L","year":"2000","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00794072"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2005.09.033"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.01.013"},{"key":"e_1_2_1_12_1","first-page":"77","article-title":"Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus","volume":"15","author":"Li SQ","year":"1995","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_1_13_1","first-page":"646","article-title":"Effect of astragalus injection on left ventricular remodeling and apoptotic gene caspase\u20103 in rats after myocardial infarction","volume":"25","author":"Ma L","year":"2005","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"e_1_2_1_14_1","first-page":"303","article-title":"Scavenging effects of Astragalus and Gynostemma pentaphyllum with its product on O2\u2212 and OH","volume":"22","author":"Ma Z","year":"1999","journal-title":"Zhong Yao Cai"},{"key":"e_1_2_1_15_1","first-page":"422","article-title":"Botanical influences on cardiovascular disease","volume":"3","author":"Miller AL","year":"1998","journal-title":"Altern Med Rev"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2004.27"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.1.R77"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.02.014"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033457656"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(85)80130-9"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00489-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.67.705"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4472-8_22"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.08.044"},{"key":"e_1_2_1_25_1","first-page":"151","article-title":"The hemodynamics of isoproterenol\u2010induced cardiac failure in the rat","volume":"8","author":"Yeager JC","year":"1981","journal-title":"Circ Shock"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.02.008"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.3.H1137"},{"key":"e_1_2_1_28_1","first-page":"300","article-title":"Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats","volume":"25","author":"Zhou JY","year":"2000","journal-title":"Zhongguo Zhong Yao Za Zhi"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T14:56:48Z","timestamp":1699973808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,4]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/ptr.2332"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2332","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,4]]}}}