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The current study was designed to investigate the pharmacological actions of individual herbs comprising FAHF\u20102 on peanut\u2010induced anaphylactic reactions in a murine model of peanut allergy and to determine if all nine herbs are necessary to prevent an anaphylactic reaction, or if a simplified formula containing fewer herbs would be equally effective. Some individual herbs reduced peanut\u2010induced anaphylactic symptoms but no single herb offered full protection from anaphylactic symptoms equivalent to FAHF\u20102. The herbs had highly variable effects on histamine release, as well as peanut\u2010specific serum IgE and IgG2a levels. The herbs also had variable effects on IL\u20104, IL\u20105 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> levels. A simplified formula comprising the most efficacious tested individual herbs showed only partial efficacy and was not able to reproduce comparably the effects of FAHF\u20102, suggesting that component herbs of FAHF\u20102 may work synergistically to produce the curative therapeutic effects produced by the whole formula, which appears to be the best option for future clinical trials. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2357","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T13:23:06Z","timestamp":1207228986000},"page":"651-659","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacological and immunological effects of individual herbs in the Food Allergy Herbal Formula\u20102 (FAHF\u20102) on peanut allergy"],"prefix":"10.1002","volume":"22","author":[{"given":"Jacob D.","family":"Kattan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal D.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong 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