{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:22:38Z","timestamp":1789500158722,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T00:00:00Z","timestamp":1213920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Funda\u00e7\u00f5es de Amparo \u00e0 Pesquisa dos Estados de Minas Gerais (FAPEMIG)"},{"name":"S\u00e3o Paulo (FAPESP)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many medicinal plants have been recommended for the treatment of snakebites. The aqueous extracts prepared from the leaves of <jats:italic>Schizolobium parahyba<\/jats:italic> (a plant found in Mata Atlantica in Southeastern Brazil) were assayed for their ability to inhibit some enzymatic and biological activities induced by <jats:italic>Bothrops pauloensis<\/jats:italic> and <jats:italic>Crotalus durissus terrificus<\/jats:italic> venoms as well as by their isolated toxins neuwiedase (metalloproteinase), BnSP\u20107 (basic Lys49 PLA<jats:sub>2<\/jats:sub>) and CB (PLA<jats:sub>2<\/jats:sub> from crotoxin complex). Phospholipase A<jats:sub>2<\/jats:sub>, coagulant, fibrinogenolytic, hemorrhagic and myotoxic activities induced by<jats:italic> B. pauloensis<\/jats:italic> and <jats:italic>C. d. terrificus<\/jats:italic> venoms, as well as by their isolated toxins were significantly inhibited when different amounts of <jats:italic>S. parahyba<\/jats:italic> were incubated previously with these venoms and toxins before assays. However, when <jats:italic>S. parahyba<\/jats:italic> was administered at the same route as the venoms or toxins injections, the tissue local damage, such as hemorrhage and myotoxicity was only partially inhibited. The study also evaluated the inhibitory effect of <jats:italic>S. parahyba<\/jats:italic> upon the spreading of venom proteins from the injected area into the systemic circulation. The neutralization of systemic alterations induced by i.m. injection of <jats:italic>B. pauloensis<\/jats:italic> venom was evaluated by measuring platelet and plasma fibrinogen levels which were significantly maintained when <jats:italic>S. parahyba<\/jats:italic> extract inoculation occurred at the same route after <jats:italic>B. pauloensis<\/jats:italic> venom injection. In conclusion, the observations confirmed that the aqueous extract of <jats:italic>S. parahyba<\/jats:italic> possesses potent snake venom neutralizing properties. It may be used as an alternative treatment to serum therapy and as a rich source of potential inhibitors of toxins involved in several physiopathological human and animal diseases. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2371","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T07:51:51Z","timestamp":1213948311000},"page":"859-866","source":"Crossref","is-referenced-by-count":23,"title":["Anti\u2010snake venom properties of <i>Schizolobium parahyba<\/i> (Caesalpinoideae) aqueous leaves extract"],"prefix":"10.1002","volume":"22","author":[{"given":"Mirian M.","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina F.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana S.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Henrique F.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00e2nia M.","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando M.","family":"Izidoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lia","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria In\u00eas","family":"Homsi\u2010Brandeburgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreimar M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veridiana M.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00189-1"},{"key":"e_1_2_1_3_1","first-page":"727","article-title":"Biochemical and biological differentiation of the venoms of the lancehead vipers (Bothrops marajoensis and Bothrops moojeni)","volume":"102","author":"Assakura MT","year":"1992","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(03)00138-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.12.014"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-0491(00)00237-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00169-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_9_1","first-page":"515","article-title":"Snake bites: appraisal of the global situation","volume":"76","author":"Chippaux JP","year":"1998","journal-title":"Bull World Health Organ"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821991000200004"},{"key":"e_1_2_1_11_1","first-page":"377","article-title":"Understanding snake venoms: 50 years of research in Latin America","volume":"50","author":"Guti\u00e9rrez JM","year":"2002","journal-title":"Rev Biol Trop"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01163-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.02.029"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(83)90262-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(03)00126-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(03)00126-3"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(89)90146-3"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90485-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.039"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90429-9"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00229-6"},{"key":"e_1_2_1_22_1","first-page":"89","article-title":"Clinical and epidemiological study of cases of lance\u2010headed vipers","volume":"86","author":"Nishioka SA","year":"1992","journal-title":"J Trop Med Parasit"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.12.028"},{"key":"e_1_2_1_24_1","unstructured":"RDCT.2005. 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