{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:27:03Z","timestamp":1791278823027,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T00:00:00Z","timestamp":1205798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>No conflicts of interest concerning financial matters or personal relationships exist between the authors and those who might bias this work. The present work is in part included the PhD thesis of A. Schinkovitz (University of Graz) but has not been published elsewhere previously.<\/jats:p><jats:p>The dichloromethane extract of the roots of <jats:italic>Levisticum officinale<\/jats:italic> L. (Apiaceae) exhibited significant antimycobacterial activity against <jats:italic>Mycobacterium fortuitum<\/jats:italic> and <jats:italic>Mycobacterium aurum<\/jats:italic> in a microtiter plate dilution assay and was further analysed following a bioassay\u2010guided fractionation strategy. 3(<jats:italic>R<\/jats:italic>)\u2010Falcarinol (3(<jats:italic>R<\/jats:italic>)\u2010(\u2010)\u20101,9\u2010heptadecadien\u20104,6\u2010diin\u20103\u2010ol] and 3(<jats:italic>R<\/jats:italic>)\u20108(<jats:italic>S<\/jats:italic>)\u2010falcarindiol [3(<jats:italic>R<\/jats:italic>)\u20108(<jats:italic>S<\/jats:italic>)\u2010(+)\u20101,9\u2010heptadecadien\u20104,6\u2010diin\u20103,8\u2010diol] could be identified as the active components in this extract. The minimal inhibitory concentration (MIC) of 3(<jats:italic>R<\/jats:italic>)\u2010falcarinol against <jats:italic>M. fortuitum<\/jats:italic> and <jats:italic>M. aurum<\/jats:italic> was 16.4 \u00b5<jats:sc>m<\/jats:sc> while that of 3(<jats:italic>R<\/jats:italic>)\u20108(<jats:italic>S<\/jats:italic>)\u2010falcarindiol was 30.7 \u00b5<jats:sc>m<\/jats:sc> against <jats:italic>M. fortuitum<\/jats:italic> and 61.4 \u00b5<jats:sc>m<\/jats:sc> against <jats:italic>M. aurum<\/jats:italic>, respectively. Previously, 3(<jats:italic>R<\/jats:italic>),8(<jats:italic>R<\/jats:italic>)\u2010dehydrofalcarindiol was isolated from <jats:italic>Artemisia monosperma<\/jats:italic> and surprisingly this polyacetylene exhibited no antimycobacterial activity at 128 \u00b5g\/mL. This indicates that the terminal methyl group is vital for retention of antimycobacterial activity. Reference antibiotics ethambutol and isoniazid exhibited an activity of 115.5 \u00b5<jats:sc>m<\/jats:sc> and 14.6 \u00b5<jats:sc>m<\/jats:sc> against <jats:italic>M. fortuitum<\/jats:italic>, and 3.4 \u00b5<jats:sc>m<\/jats:sc> and 29.2 \u00b5<jats:sc>m<\/jats:sc> against <jats:italic>M. aurum<\/jats:italic>, respectively. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2408","type":"journal-article","created":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T13:46:46Z","timestamp":1205848006000},"page":"681-684","source":"Crossref","is-referenced-by-count":51,"title":["Antimycobacterial polyacetylenes from <i>Levisticum officinale<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Andreas","family":"Schinkovitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Stavri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Bucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"386","volume-title":"Proceedings of Food and Cancer Prevention III Meeting: Dietary Anticancerogens and Antimutagens,","author":"Brandt K","year":"2000"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.198419840221"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50099a022"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf034085"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)10193-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8137.1979.tb07471.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.12.031"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-005-2494-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<139::AID-PTR608>3.0.CO;2-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1987.tb02634.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np970182j"},{"key":"e_1_2_1_13_1","first-page":"232","volume-title":"Tuberculosis: Current Concepts and Treatment","author":"Lakely DL","year":"2001"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2003.11.010"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470210_5.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00391-6"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957872"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2004.12.009"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38876"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.11.010"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1758"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1527"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8624"},{"key":"e_1_2_1_24_1","first-page":"1913","article-title":"Studies on the control of fatty acid metabolism II. 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