{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:30:20Z","timestamp":1774927820895,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","award":["NIH SBIR Phase I grant 1R43DE015741-01A1"],"award-info":[{"award-number":["NIH SBIR Phase I grant 1R43DE015741-01A1"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is a major cause of tooth motility and loss, resulting in destruction of the supporting structures of the tooth, including periodontal ligaments and alveolar bone. Periodontal surgery can slow the progression of the disease, but is costly, invasive, limited by contraindications and technique\u2010sensitive. Recently, non\u2010invasive pharmacological treatments using proteinaceous biologicals have become available. Here, for the first time, the bone\u2010regenerative capabilities of a non\u2010proteinaceous biological \u2013 SBD.4A \u2013 a novel, stable multicomponent growth factor isolated from a medicinal plant <jats:italic>Angelica sinensis<\/jats:italic> are reported. SBD.4A was tested in osteoblast proliferation and differentiation systems, as well as in a fibroblast\u2010secreted hyaluronic acid assay. Furthermore, SBD.4A was formulated in a slow release matrix and tested in the rat calvarial defect model. Apart from the previously reported strong stimulation of angiogenesis, fibroblast growth and collagen synthesis \u2013 the activities needed for periodontal regeneration \u2013 SBD.4A enhanced the deposition of hyaluronic acid and proliferation of osteoblasts <jats:italic>in vitro<\/jats:italic>, as well as bone regeneration in the rat calvarial defect model. Together, these results indicate the beneficial effect of SBD.4 on periodontal ligament and bone regeneration making the case for further development of this botanical growth factor. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2421","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T13:23:49Z","timestamp":1207229029000},"page":"923-928","source":"Crossref","is-referenced-by-count":6,"title":["Effect of SBD.4A \u2013 a defined multicomponent preparation of <i>Angelica sinensis<\/i> \u2013 in periodontal regeneration models"],"prefix":"10.1002","volume":"22","author":[{"given":"Hui","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexei","family":"Alexeev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vrushali","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo Dave T.","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Bojanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,20]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"388","article-title":"Human mesothelioma cells produce factors that stimulate the production of hyaluronan by mesothelial cells and fibroblasts","volume":"53","author":"Asplund T","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010401"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1263\/jbb.103.1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.120609.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00146.x"},{"key":"e_1_2_1_7_1","first-page":"935","article-title":"Position paper: epidemiology of periodontal diseases. 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