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Compounds 1\u20137 were evaluated as inhibitors of some macrophage functions involved in the inflammatory process. These seven compounds significantly and dose dependently inhibited lipopolysaccharide (LPS) and interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic>induced nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)\u2010<jats:italic>\u03b1<\/jats:italic>and interleukin (IL)\u201012]. The concentration causing a 50% inhibition (IC<jats:sub>50<\/jats:sub>) of NO, TNF\u2010<jats:italic>\u03b1<\/jats:italic>and IL\u201012 production by compounds 1, 2 and 7 was approximately 30, 50 and 10 \u00b5M, respectively, while at 50, 200 and 40 \u00b5M compounds 3, 4, and 5, 6 showed 15\u201330% inhibition, respectively. On the other hand, compounds 3 and 7 showed no inhibitory effect, while compounds 1, 4\u20136 reduced by around 10\u201330% the synthesis of NO by macrophages, when inducible NO synthase was already expressed with LPS\/IFN\u2010<jats:italic>\u03b3<\/jats:italic>for 24 h. These experimental findings lend pharmacological support to the suggested folkloric uses of the plant<jats:italic>B. variegata<\/jats:italic>in the management of inflammatory conditions. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2448","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T10:46:32Z","timestamp":1207219592000},"page":"957-962","source":"Crossref","is-referenced-by-count":62,"title":["Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from<i>Bauhinia variegata<\/i>"],"prefix":"10.1002","volume":"22","author":[{"given":"Yerra 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