{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:07:01Z","timestamp":1759529221967,"version":"3.35.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T00:00:00Z","timestamp":1213920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A water\u2010soluble extract of a traditional Chinese fermented black tea, pu\u2010ehr, decomposes bile acid cholesterol micelles. This black tea extract (BTE) was studied to see if it could decrease the postprandial elevation of blood cholesterol levels after a single administration in ddY mice. It was found that BTE (0.3 g\/kg) significantly decreased the postprandial rise in blood cholesterol levels after oral administration of cholesterol (130 mg\/kg). A non\u2010fermented tea (i.e. green tea) extract did not prevent the postprandial increase in blood cholesterol. In a subsequent study, 5\u2010week\u2010old Sprague\u2013Dawley (SD) rats were fed BTE for 3 weeks, following which a dose\u2010dependent and significant decrease in serum total cholesterol levels (1.36 mmol\/L, 0.1% BTE,<jats:italic>p<\/jats:italic>&lt; 0.05) was found and also in renal fat weight (0.3% BTE,<jats:italic>p<\/jats:italic>&lt; 0.05). LDL cholesterol levels (0.51 mmol\/L, 0.1% BTE,<jats:italic>p<\/jats:italic>&lt; 0.05) were also significantly decreased. There were no significant changes in the weights of other organs or in the serum levels of other clinical markers. Thus, BTE has a specific antihypercholesterol effect in rodents, which might potentially aid in the management of hyperlipidaemia in man. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2477","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T15:19:49Z","timestamp":1213975189000},"page":"1275-1281","source":"Crossref","is-referenced-by-count":20,"title":["Extract of black tea (pu\u2010ehr) inhibits postprandial rise in serum cholesterol in mice, and with long term use reduces serum cholesterol and low density lipoprotein levels and renal fat weight in rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Hiroyuki","family":"Fujita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohide","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508033330502"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/jn\/129.6.1094","article-title":"Jasmine green tea epicatechins are hypolipidemic in hamsters fed a high fat diet","volume":"129","author":"Chan PT","year":"1999","journal-title":"J Nutr"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.8.2105"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1211"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(99)00118-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2000.tb16049.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.65.72"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(92)90269-2"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38403-0"},{"key":"e_1_2_1_11_1","unstructured":"1996 National Academy Press ILAR (Institute for Laboratory Animal Research)\u2010NRC (National Research Council) Guide for the care and use of Iaboratory animals"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(96)01449-3"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf049375k"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.11.2844"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.5.826"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.407"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/ajcn\/33.4.787","article-title":"A novel use of chitosan as a hypo\u2010cholesterolemic agent in rats.","volume":"33","author":"Sugano M","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199705000-00018"},{"key":"e_1_2_1_20_1","first-page":"2189","article-title":"Reduction of body fat in humans by long\u2010term ingestion of catechins","volume":"22","author":"Tsuchida T","year":"2002","journal-title":"Prog Med"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703235"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3565(24)36992-7","article-title":"In vivo metabolism\u2010based discovery of potent cholesterol absorption inhibitor, SCH58235, in the rat and rhesus monkey through the identification of the active metabolism of SCH58235","volume":"283","author":"Von Heek M","year":"1997","journal-title":"J Pharm Exp Ther"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.15.1440"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1997.0176"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2477","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T19:49:20Z","timestamp":1738266560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,20]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1002\/ptr.2477"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2477","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"type":"print","value":"0951-418X"},{"type":"electronic","value":"1099-1573"}],"subject":[],"published":{"date-parts":[[2008,6,20]]}}}