{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:53:04Z","timestamp":1792504384702,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T00:00:00Z","timestamp":1226361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here we evaluate the effects of ethanol and aqueous extracts from <jats:italic>Cortex Lycii Radicis<\/jats:italic> (CLR) on insulin resistance and lipid metabolism in obese\u2010diabetic rats, which were induced by high fat feeding for 3 weeks after injection with streptozotocin (STZ). Diabetic rats treated with ethanol or aqueous extracts of CLR at 15 and 30 g\/kg dosage for 7 weeks, had decreased body weights, concentration of serum glucose, triglyceride (TG), total cholesterol (TC), and low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), while the insulin\u2010sensitivity index (ISI) improved significantly compared with the control group. In addition, high contents of tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>), interleukin\u20106 (IL\u20106) and low adiponectin level were observed in the control group and levels of TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20106 in CLR groups showed obvious differences with the control group. Histopathologic examination also showed degrees of hepatocyte edema although hepatocyte ballooning degeneration was lessened in all CLR groups. Overall, ethanol extract from CLR seemed to be more effective than aqueous extracts in improving insulin resistance, resulted in elevating insulin sensitivity, adjusting glucose and lipid metabolism, correcting cytokines levels and ameliorating liver function, especially protecting the liver against lipoid degeneration. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2552","type":"journal-article","created":{"date-parts":[[2008,11,11]],"date-time":"2008-11-11T12:03:22Z","timestamp":1226405002000},"page":"1665-1670","source":"Crossref","is-referenced-by-count":36,"title":["Cortex Lycii Radicis extracts improve insulin resistance and lipid metabolism in obese\u2010diabetic rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhen","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Xiang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard JP","year":"2006","journal-title":"European Cytokine Network"},{"key":"e_1_2_1_3_1","first-page":"116","article-title":"Experiment study of Digupi on hypoglycemic effects","volume":"18","author":"Bo Ping","year":"1993","journal-title":"J Chin Mat Med"},{"key":"e_1_2_1_4_1","first-page":"30P","article-title":"Relative analysis between cerebral infarction and the insulin resistance","volume":"20","author":"Chen ZhanYin","year":"2000","journal-title":"Chinese Journal of Practical Internal Medicine"},{"key":"e_1_2_1_5_1","first-page":"1611","article-title":"Study on bioactive ingredients in Cortex Lycii by capillary zone electrophoresis with amperometric detection","volume":"33","author":"Chu QingCui","year":"2005","journal-title":"Chinese J Anal Chem"},{"key":"e_1_2_1_6_1","first-page":"274","volume":"7","author":"Editor Committee of Chinese Bencao of State Administration of Traditional Chinese Medicine","year":"1999","journal-title":"Chinese Bencao Science and Technology Press"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00337-5"},{"key":"e_1_2_1_8_1","first-page":"229","article-title":"Effect of relieving fever and reducing plasma glucose of 3 kinds of Digupi on albino rats","volume":"29","author":"Huang XiaoHong","year":"2000","journal-title":"Journal of Fujlan Agricultural University"},{"key":"e_1_2_1_9_1","first-page":"108","article-title":"Antidiabetic drugs of plant origin used in China: compositions, pharmacology, and hypoglycemic mechanisms","volume":"28","author":"Jia Wei","year":"2003","journal-title":"J Chin Mat Med"},{"key":"e_1_2_1_10_1","first-page":"185","article-title":"Study on stroke syndrome of Chinese medicine and its relationship with blood hypercoagalative status and insulin resistance in diabetic ischemic stroke patients","volume":"22","author":"Li ChuangPeng","year":"2002","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_1_11_1","first-page":"656","article-title":"A new insulin\u2010sensitivity index for the population\u2010based study","volume":"32","author":"Li GuangWei","year":"1993","journal-title":"Chinese J Intern Med"},{"key":"e_1_2_1_12_1","first-page":"424","article-title":"Hypoglycemic effects of different compositions of Cortex Lycii Radicis(CLR) in aalloxan diabetic mice","volume":"23","author":"Li Kang","year":"2001","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"key":"e_1_2_1_13_1","unstructured":"LiangXingLun HanMingXiang.2001. 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