{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:23:37Z","timestamp":1791167017594,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T00:00:00Z","timestamp":1218412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD). Phytoestrogens such as genistein have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether genistein administration at a high dose would attenuate behavioral and structural abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6\u2010hydroxydopamine (6\u2010OHDA, 12.5 \u00b5g\/5 \u00b5L of saline\u2010ascorbate)\u2010lesioned rats were intraperitoneally pretreated with a single and high dose of genistein (10 mg\/kg) 1 h before surgery. Apomorphine\u2010induced rotations and the number of Nissl\u2010stained neurons in the substantia nigra pars compacta (SNC) were counted after 2 weeks. Genistein administration could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6\u2010OHDA toxicity. Genistein administration has a protective effect against 6\u2010OHDA toxicity. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2564","type":"journal-article","created":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T08:17:18Z","timestamp":1218442638000},"page":"132-135","source":"Crossref","is-referenced-by-count":72,"title":["Neuroprotective effect of genistein in 6\u2010hydroxydopamine Hemi\u2010parkinsonian rat model"],"prefix":"10.1002","volume":"23","author":[{"given":"Tourandokht","family":"Baluchnejadmojarad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Roghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza Jalali","family":"Nadoushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500519161"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8503"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90447-A"},{"key":"e_1_2_1_5_1","first-page":"12","article-title":"Estrogenic modulation of brain activity: implications for schizophrenia and Parkinson's disease","volume":"27","author":"Cyr M","year":"2002","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00568-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00066.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05775"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00018-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10315"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66051836.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200002070-00024"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13148-7"},{"key":"e_1_2_1_14_1","first-page":"118","article-title":"Gender differences in Parkinson's disease","volume":"21","author":"Lyons KE","year":"1998","journal-title":"Clin Neuropharmacol"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1058"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90605-X"},{"key":"e_1_2_1_18_1","first-page":"689","article-title":"Behavioral and neurochemical dynamics of neurotoxic meso\u2010striatal dopamine lesions","volume":"18","author":"Schwarting RK","year":"1997","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(96)00040-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90885-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623100505"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200519090-00001"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2564","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T02:18:51Z","timestamp":1699928331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,11]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/ptr.2564"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2564","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,11]]}}}