{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:13:40Z","timestamp":1700007220933},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T00:00:00Z","timestamp":1236556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Problems of eye contact and expressive language limit the effectiveness of educational and behavioral interventions in patients suffering from pervasive developmental disorders. For that reason, additive psychopharmacological interventions are sometimes needed to improve symptomatology. In our preliminary open trial, three male patients with autistic disorder, diagnosed by ICD\u201010 criteria, completed an open trial of St John's Wort. Subjects were included in the study if their eye contact and expressive language was inadaequate for their developmental level and if they had not tolerated or responded to other psychopharmacologic treatments (methylphenidate, clonidine or desipramine). Parent and mentor ratings on the Aberrant Behavior Checklist, irritability, stereotypy, and inappropriate speech factors improved slightly during treatment with St John's Wort. Clinician ratings (Psychiatric Rating Scale Autism, Anger and Speech Deviance factors; Global Assessment Scale; Clinical Global Impressions efficacy) did not improve significantly. St John's Wort was only modestly effective in the short\u2010term treatment of irritability in some patients with autistic disorder. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2580","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T16:20:58Z","timestamp":1236615658000},"page":"1521-1523","source":"Crossref","is-referenced-by-count":5,"title":["St John's Wort treating patients with autistic disorder"],"prefix":"10.1002","volume":"23","author":[{"given":"Helmut","family":"Niederhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,10,23]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"492","article-title":"Psychometric characteristics of the Aberrant Behavior Checklist","volume":"99","author":"Amman MG","year":"1985","journal-title":"Am J Ment Def"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-198803000-00020"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/070674378102600414","article-title":"Pharmacotherapy for autistic children, a summary of research","volume":"26","author":"Campbell M","year":"1951","journal-title":"Can J Psychiatry"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538168"},{"key":"e_1_2_1_6_1","first-page":"251","article-title":"Tardive and withdrawal dyskinesia in autistic children: a prospective study","volume":"24","author":"Campbell M","year":"1985","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890060309"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(87)90218-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/10645-000"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-7138(09)60065-0"},{"key":"e_1_2_1_11_1","first-page":"322","article-title":"Clonidine treatment of hyperactive and impulsive children with autistic disorder","volume":"5","author":"Jaselskis CA","year":"1992","journal-title":"J Clin Psychopharm"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1977.01770170063005"},{"key":"e_1_2_1_13_1","first-page":"839","article-title":"Special feature: rating scales and assessment instruments for use in pediatric psychopharmacology research","volume":"21","author":"National Institute of Mental Health","year":"1985","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(198809)44:5<708::AID-JCLP2270440507>3.0.CO;2-T"},{"key":"e_1_2_1_15_1","first-page":"57","article-title":"Long\u2010term efficacy of haloperidol in autistic children: Continuous versus discontinuous drug administration","volume":"25","author":"Perry R","year":"1959","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790100074010"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2580","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:56:24Z","timestamp":1699959384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,23]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/ptr.2580"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2580","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,23]]}}}