{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:32:07Z","timestamp":1771489927605,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T00:00:00Z","timestamp":1219363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dysfunction of the <jats:italic>NF1<\/jats:italic> gene coding a RAS GAP is the major cause of neurofibromatosis type 1 (NF1), whereas neurofibromatosis type 2 (NF2) is caused primarily by dysfunction of the <jats:italic>NF2<\/jats:italic> gene product called merlin that inhibits directly PAK1, an oncogenic Rac\/CDC42\u2010dependent Ser\/Thr kinase. It was demonstrated previously that PAK1 is essential for the growth of both NF1 and NF2 tumors. Thus, several anti\u2010PAK1 drugs, including FK228 and CEP\u20101347, are being developed for the treatment of NF tumors. However, so far no effective NF therapeutic is available on the market. Since propolis, a very safe healthcare product from bee hives, contains anticancer ingredients called CAPE (caffeic acid phenethyl ester) or ARC (artepillin C), depending on the source, both of which block the oncogenic PAK1 signaling pathways, its potential therapeutic effect on NF tumors was explored <jats:italic>in vivo<\/jats:italic>. Here it is demonstrated that Bio 30, a CAPE\u2010rich water\u2010miscible extract of New Zealand (NZ) propolis suppressed completely the growth of a human NF1 cancer called MPNST (malignant peripheral nerve sheath tumor) and caused an almost complete regression of human NF2 tumor (Schwannoma), both grafted in nude mice. Although CAPE alone has never been used clinically, due to its poor bioavailability\/water\u2010solubility, Bio 30 contains plenty of lipids which solubilize CAPE, and also includes several other anticancer ingredients that seem to act synergistically with CAPE. Thus, it would be worth testing clinically to see if Bio 30 and other CAPE\u2010rich propolis are useful for the treatment of NF patients. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2594","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T14:29:14Z","timestamp":1219415354000},"page":"226-230","source":"Crossref","is-referenced-by-count":73,"title":["CAPE (caffeic acid phenethyl ester)\u2010based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice"],"prefix":"10.1002","volume":"23","author":[{"given":"M.","family":"Demestre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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