{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:23:03Z","timestamp":1790724183741,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T00:00:00Z","timestamp":1223510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Lantana camara<\/jats:italic> is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study was to investigate excision wound healing activity of the leaf extract of <jats:italic>L. camara<\/jats:italic> in rats. The animals were divided into two groups of 12 each in both the models. The test group animals were treated with the aqueous extract of <jats:italic>L. camara<\/jats:italic> (100 mg\/kg\/day<jats:italic>)<\/jats:italic> topically and the control group animals were left untreated. Wound healing efficacy was measured by determining the morphological and biochemical parameters. Wound healing time, wound contraction and synthesis of collagen were monitored periodically. Antimicrobial activities of the extract against the microorganisms were also assessed. Treatment of the wounds with extract enhanced significantly the rate of wound contraction (98%), synthesis of collagen and decreased mean wound healing time. These studies demonstrate that <jats:italic>L. camara<\/jats:italic> is effective in healing excision wounds in the experimental animal and could be evaluated as a therapeutic agent in tissue repair processes associated with skin injuries. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2599","type":"journal-article","created":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T12:54:10Z","timestamp":1223556850000},"page":"241-245","source":"Crossref","is-referenced-by-count":52,"title":["Evaluation of wound healing activity of <i>Lantana camara<\/i> L. \u2013 a Preclinical study"],"prefix":"10.1002","volume":"23","author":[{"given":"B. Shivananda","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Sivachandra","family":"Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Eversley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adash","family":"Ramsubhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(96)00805-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50124a014"},{"key":"e_1_2_1_4_1","volume-title":"Lantana: Current Management, Status and Future Prospects","author":"Day MD","year":"2003"},{"key":"e_1_2_1_5_1","first-page":"394","volume-title":"La Flore du B\u00e9nin","author":"De Souza S","year":"1988"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(00)00202-1"},{"key":"e_1_2_1_7_1","first-page":"279","volume-title":"Photochemical Methods: A Guide to Modern Techniques of Plant Analysis.","author":"Harborne JB","year":"1973"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl336"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.08.009"},{"key":"e_1_2_1_10_1","first-page":"263","article-title":"Controversy of free radical hypothesis: reactive oxygen species \u2013 cause or consequence of tissue injury?","volume":"24","author":"Juranek I","year":"2005","journal-title":"Gen Physiol Biophys"},{"key":"e_1_2_1_11_1","first-page":"297","article-title":"Survey of Indian medicinal plants for saponins. Alkaloids and flavonoids","volume":"32","author":"Kapoor LD","year":"1969","journal-title":"Lloydia"},{"key":"e_1_2_1_12_1","first-page":"371","article-title":"\u03b2\u2010Adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle","volume":"44","author":"Kumar R","year":"2006","journal-title":"Indian J Exp Biol"},{"key":"e_1_2_1_13_1","first-page":"117","article-title":"Evaluation of vulnerary activity by an open wound procedure in rats","volume":"196","author":"Morton JJP","year":"1972","journal-title":"Arch Int Pharmacodyn"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)51149-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(98)00003-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1977.tb00195.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(88)90196-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(98)00382-8"},{"key":"e_1_2_1_19_1","first-page":"686","article-title":"An improved procedure for isolation and purification of lantadene A, the bioactive pentacyclic triterpenoid from Lantana camara leaves","volume":"21","author":"Sharma S","year":"1999","journal-title":"J Med Aromatic Plant Sci"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.2599","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.2599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T08:15:41Z","timestamp":1697098541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.2599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,9]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/ptr.2599"],"URL":"https:\/\/doi.org\/10.1002\/ptr.2599","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,9]]}}}