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The rats were randomly assigned to five groups: control group (olive oil injection), CCl<jats:sub>4<\/jats:sub> group (CCl<jats:sub>4<\/jats:sub> injection), silymarin group (CCl<jats:sub>4<\/jats:sub> injection combined with supplementation of silymarin, 7.5 mg\/kg\/day), low dose group (CCl<jats:sub>4<\/jats:sub> injection combined with supplementation of schisandrin B and sesamin mixture at a low dose, 43 mg\/kg\/day) and high dose group (CCl<jats:sub>4<\/jats:sub> injection combined with the supplementation of schisandrin B and sesamin mixture at a high dose, 215 mg\/kg\/day). The hepatic superoxide dismutase and glutathione peroxidase activities of rats in the low dose and high dose groups were increased significantly compared with those in the CCl<jats:sub>4<\/jats:sub> group. The hepatic reduced glutathione concentration in the silymarin, low dose and high dose groups were increased significantly (48%, 45% and 53%, respectively) when compared with those of the CCl<jats:sub>4<\/jats:sub> group. In addition, the concentration of glutathione in the erythrocytes of the low dose group was significantly higher than the CCl<jats:sub>4<\/jats:sub> group by 25%. These results suggest that the schisandrin B\u2013sesamin mixture exerted a hepatoprotective effect by improving the antioxidative capacity in rats under CCl<jats:sub>4<\/jats:sub>\u2010induced hepatic oxidative stress. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.2602","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T12:02:28Z","timestamp":1225454548000},"page":"251-256","source":"Crossref","is-referenced-by-count":28,"title":["Effect of schisandrin B and sesamin mixture on CCl<sub>4<\/sub>\u2010induced hepatic oxidative stress in 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